Manal Ali Buabeid

Manal Ali Buabeid

Associate Professor
Ext: 6058

Dr. Manal Buabeid is currently an Associate Professor in the Department of Clinical Sciences-College of Pharmacy and Health Sciences at Ajman University. she graduated from Auburn University-USA where she earned her PhD. in Neuropharmacology from the Department of Drug Discovery and Development. She received the American Federation Pharmaceutical Education (AFPE) Award in 2012. The major focus of her research centers around synaptic mechanisms of learning and memory. Specifically, to elucidate the regulation of glutamate receptor-mediated synaptic transmission in animal models of diseases such as Alzheimer’s disease, epilepsy and diabetes, and the use of experimental drugs to ameliorate the synaptic dysfunction and associated neurobehavioral deficits in these disease states. Published several research papers in peer-reviewed journals. She has authored several abstracts presented in local, national and international conferences and received several awards for research and academic excellence

Education
  • 2013 PhD from Harrison School of Pharmacy, -Department of Pharmacal Sciences (Drug discovery and Development ), , Auburn University, United States.
  • 2004 M.Phil. Neuropharmacology, Department of Biological Sciences, University of Manchester, UK.
  • 1992 B.Sc. Pharmacy, Tripoli University
Experience
  • 2018-Present Position Assistant professor: School of Pharmacy, Department of Clinical Sciences
  • 2015-2018 Position Assistant professor: School of Pharmacy, Department of Pharmacy practice
  • 2012-2015(summer) Teaching Biology ( Neurobiology), community college, Auburn , USA.
  • 2009 - 2015 Teaching Assistant for Pharmacology courses and Research Assistant in Neuropharmacology .
  • 2004 - 2007 Position: Senior Lecturer/Lecturer: School of Pharmacy, Department of Pharmacology, Therapeutics and Clinical Pharmacy, University of Tripoli, Libya.
Teaching Area
  • Pharmacology II and III for Pharmacy Students, Pharmacology II for dentistry students, Toxicology and chemotherapy for Pharmacy Students.
Research
  • My major area of research can be described as molecular and pharmacology. More specifically my research interest is on understanding the mechanisms regulating excitatory synaptic function the mammalian hippocampus. I study if changes in synaptic function are paralleled by molecular changes in trafficking of synaptic proteins and intracellular signaling molecules and also by behavioral changes, mainly learning and memory. Synaptic physiology is studied by electrophysiological analyses of a set of synapses from a region as well as from a single neuron. In addition I utilize sophisticated single channel analysis, including computer modeling to understand channel kinetics, to identify molecular and cellular processes that shape the excitatory physiology of synapses in the hippocampus.
Publications
  • Buabeid M. et al. (2021) Neuroprotective Effects of Portulaca oleracea and Portulaca quadrifida Linn. In: Agrawal D.C., Dhanasekaran M. (eds) Medicinal Herbs and Fungi. Springer, Singapore. https://doi.org/10.1007/978-981-33-4141-8_20
  • Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease Author links open overlay panelManojGovindarajulua1SindhuRamesha1LoganNeelaMaryFabbriniaManalBuabeidNeurochemistry International Volume 144, March 2021, 104958
  • Patient Safety Culture in Handling Prescriptions and Interprofessional Collaboration Practices Amongst Community Pharmacists: An Investigative Simulated Patient Study from the … S Palaian, M Buabeid, A Ashames Risk Management and Healthcare Policy 13, 3201 (2020)
  • Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats ESA Arafa, W Hassan, G Murtaza, MA Buabeid Journal of Diabetes Research 2020
  • Calcitonin and bone physiology: in vitro, in vivo, and clinical investigations J Xie, J Guo, Z Kanwal, M Wu, X Lv, NA Ibrahim, P Li, MA Buabeid, ... International Journal of Endocrinology 2020
  • Potential risk of subclinical iron deficiency anemia in misinterpretation of glycosylated hemoglobin a1c (hba1c): a case report MB S.Bakr Hematology, Transfusion and Cell Therapy 42 (Volume 42, Supplement 1(2020) …
  • Nanocomposites drug delivery systems for the healing of bone fractures J Chen, A Ashames, MA Buabeid, KM Fahelelbom, M Ijaz, G Murtaza International Journal of Pharmaceutics, 119477 (2020)
  • Effectiveness of testosterone therapy in hypogonadal patients and its controversial adverse impact on the cardiovascular system ZJ Kharaba, MA Buabeid, YA Alfoteih Critical Reviews in Toxicology 50 (6), 491-512 (2020)
  • Exploring community pharmacists perception towards responsible provision of patient care services: A quantitative assessment Z Kharaba, R Kousar, S Azhar, MA Buabeid, SA Khan, G Murtaza Tropical Journal of Pharmaceutical Research 19 (4), 879-885 (2020)
  • Testosterone therapy in hypogonadal patients and the associated risks of cardiovascular events ZJ Kharaba, MA Buabeid, NA Ibrahim, FJ Jirjees, HJ Al Obaidi, ... Biomedicine & Pharmacotherapy 129, 110423 (2020)
  • In Silico Prediction of the Mode of Action of Viola odorata in Diabetes MA Buabeid, ESA Arafa, W Hassan, G Murtaza BioMed Research International 2020
  • Histological Changes in the Endometrium of Female Albino Rat Uterusunder the Effect of Clomiphene Citrate (CC) MAB Kadreya E. El Morshedy1 , Thanaa A. Elmasry2 Journal of American Science 2020;16(2)
  • Effectiveness of Conventional Versus Low-Dose Oral Isotretinoin in the Treatment of Moderate to Severe Acne U Almas, ZJ Kharaba, M Khalid, MA Buabeid, F Sattar, R Tahir, F Nighat, ... LATIN AMERICAN JOURNAL OF PHARMACY 39 (5), 986-990 (2020)
  • Synthesis, in vitro characterization and antibacterial efficacy of moxifloxacin-loaded chitosan-pullulan-silver-nanocomposite films A Shah, AA Ashames, MA Buabeid, G Murtaza Journal of Drug Delivery Science and Technology 55, 101366,2020
  • Protective effects of Cocos nucifera oil in Paraphenylene diamine toxicity ESA Arafa, MA Buabeid, W Hassan, G Murtaza, TA Chohan, H Ahmed Current pharmaceutical biotechnology (2020)
  • Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation K Rehman, SM Munawar, MSH Akash, MA Buabeid, TA Chohan, M Tariq, ... PloS one 15 (1), e0227637 2020
  • Cuscuta reflexa Roxb. Expedites the Healing Process in Contact Frostbite W Hassan, MA Buabeid, U Kalsoom, S Bakht, I Akhtar, F Iqbal, ESA Arafa BioMed research international 2020
  • Enhancing Spatial Memory Effects of Black Seed, Frankincense, and Ginger Extracts Using Albino Mice SM Aburawi, MA Buabeid, A Auzi, MM Mahmud, MA Buabeid, RA Altubuly Journal of Pharmacy and Pharmacology 8, 245-262 (2020)
  • Potential therapy of vitamin B17 against Ehrlich solid tumor induced changes in Interferon gamma, Nuclear factor kappa B, DNA fragmentation, p53, Bcl2, survivin, VEGF and TNF-α … AAG Thanaa El-Masry1,4, Nora Al-Shaalan2, Ehab Tousson3, Manal Buabeid1 Pak. J. Pharm. Sci., Vol.33, No.1(Suppl), January 2020, pp.393-401
  • Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity D Bhattacharya, A Fujihashi, M Majrashi, J Bloemer, S Bhattacharya,M. Buabeid Heliyon 6 (1), e03045, 2020
  • Effect of clarithromycin pre-treatment on the pharmacokinetics of metoclopramide after their simultaneous oral intake I Kaukab, SNH Shah, ZJ Kharaba, MA Buabeid, YA Alfoteih, G Murtaza Expert Opinion on Drug Metabolism & Toxicology 16 (8), 735-740 (2020)
  • Nanoparticle-mediated therapy of neuronal damage in the neonatal brain W Zhou, Y Fu, M Zhang, MA Buabeid, M Ijaz, G Murtaza Journal of Drug Delivery Science and Technology, 102208 ( 2020)
  • Targeting of protein expression in renal disease using siRNA–A review MA Buabeid, NA Ibrahim, ZJ Kharaba, MI Umar, G Murtaza Tropical Journal of Pharmaceutical Research 19 (6), 1313-1320
  • Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy MA Buabeid, ESA Arafa, G Murtaza Journal of Immunology Research 2020
  • Role of the purinergic P2Y2 receptor in hippocampal function in mice A Alhowail, LX Zhang, M Buabeid, JZ Shen, V Suppiramaniam European Review for Medical and Pharmacological Sciences 24 (22), 11858-11864 (2020)
  • The therapeutic and antineoplastic effects of vitamin B17 against the growth of solid-form Ehrlich tumours and the associated changes in oxidative stress, DNA damage, apoptosis … TA El-Masry, NH Al-Shaalan, E Tousson, M Buabeid, AM Alyousef Pak. J. Pharm. Sci 32 (6), 2801-2810, 2020
  • A System-Level Investigation into the Mechanisms of Apigenin Against Inflammation Y Xie, D Liang, Q Wu, X Chen, MA Buabeid, Y Wang Natural Product Communications 14 (9), 1934578X19878600, 2019
  • PPAR-δ Activation Ameliorates Diabetes-Induced Cognitive Dysfunction by Modulating Integrin-linked Kinase and AMPA Receptor Function EA Abdel-Rahman, S Bhattacharya, M Buabeid, M Majrashi, J Bloemer, ... Journal of the American College of Nutrition 38 (8), 693-702, 2019
  • Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation AH Alhowail, J Bloemer, M Majrashi, PD Pinky, S Bhattacharya, Z Yongli,M. Buabeid Toxicology mechanisms and methods 29 (6), 457-466, 2019
  • Pectin-based (LA-co-MAA) Semi-IPNS as a Potential Biomaterial for Colonic Delivery of Oxaliplatin SKY Kaleem Ullah, Muhammad Sohail, Manal Buabeid, Ghulam Murtaza International Journal of Pharmaceutics, 2019
  • Synthesis, Characterization and Safety Profiling of Eudragit-Based pH-Responsive Hydrogels: A Promising Platform for Colonic Delivery of Losartan Potassium S Mahmood, MA Buabeid, K Ullah, G Murtaza, A Mannan, SA Khan Current Drug Delivery 16 (6), 548-564, 2019
  • The wound healing and antibacterial potential of triple-component nanocomposite (chitosan-silver-sericin) films loaded with moxifloxacin A Shah, MA Buabeid, ESA Arafa, I Hussain, L Li, G Murtaza International journal of pharmaceutics 564, 22-38, 2019
  • Overview of Therapeutic Efficacy of Mushrooms S Ramesh, M Majrashi, M Almaghrabi, M Govindarajulu, E Fahoury, M Buabeid. Medicinal Mushrooms, 103-141,2019
  • Role of Nicotine Mediated Neuroprotection in MPTP-induced Parkinson’s disease ESA Arafa, M Buabeid The FASEB Journal 33 (1_supplement), lb84-lb84, 2019
  • Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease M Ahuja, M Buabeid, E Abdel-Rahman, M Majrashi, K Parameshwaran, ... Life sciences 177, 49-59, 2017
  • Altered AMPA receptor expression plays an important role in inducing bidirectional synaptic plasticity during contextual fear memory reconsolidation S Bhattacharya, W Kimble, M Buabeid, D Bhattacharya, J Bloemer, ... Neurobiology of learning and memory 139, 98-108, 2017
  • Impaired ILK function is associated with deficits in hippocampal based memory and synaptic plasticity in a FASD rat model D Bhattacharya, EP Dunaway, S Bhattacharya, J Bloemer, M Buabeid, ... PloS one 10 (8), 2015
  • Long term alterations in synaptic physiology, expression of β2 nicotinic receptors and ERK1/2 signaling in the hippocampus of rats with prenatal nicotine exposure K Parameshwaran, MA Buabeid, S Bhattacharya, S Uthayathas, ... Neurobiology of learning and memory 106, 102-111,2103
  • Anti-oxidative and DNA Protecting Effects of Flavonoids-rich Scutellaria Lateriflora M Lohani, M Ahuja, MA Buabeid, D Schwartz, D Shannon, ... Natural product communications 8 (10), 1934578X1300801019, 2013
  • Investigate the chronic neurotoxic effects of diquat SS Karuppagounder, M Ahuja, M Buabeid, K Parameshwaran, ... Neurochemical research 37 (5), 1102-1111, 2012
  • Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus K Parameshwaran, MA Buabeid, SS Karuppagounder, S Uthayathas, ... Cellular and Molecular Life Sciences 69 (5), 829-841, 2012
  • Ion Channels PK Suppiramaniam V, Buabeid MA, Bhattacharya S reference Module in Biomedical Research/ Elsevier., 2014
  • Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity D Bhattacharya, A Fujihashi, M Majrashi, J Bloemer, S Bhattacharya, ... Heliyon 6 (1), e03045 (2020)
Conference Presentation
  • Role of Nicotine Mediated Neuroprotection in MPTP-induced Parkinson’s disease ESA Arafa, M Buabeid The FASEB Journal 33 (1_supplement), lb84-lb84, 2019
  • Buabeid, Almassry, Ibrahim. Histological changes in the endometium of female albino rat uterus under the effect of clomiphene citrate (CC). ADPHAC2019, UAE.
  • Bhattacharya S, Buabeid MA, Bhattacharya D., Escobar M., Dhanasekaran M, Suppiramaniam V. “Molecular Mechanisms of Memory Reconsolidation and Retrieval”, Society of Neuroscience, San Diego, 2013
  • Abdel-Rahman EA, Buabeid M, Shonesy B, Parameshwaran K, Thiruchelvam K, Ahuja M, Dhanasekaran M, Judd R, Amin RH, Pinkert CA, Tao Y, Suppiramaniam V. (2011) Role of integrin linked kinase in diabetes induced memory loss. Fourth annual research day of Boshell Diabetes and Metabolic Diseases Research Program: 47.
  • Buabeid M. A., Abdel-Rahman E., Parameshwaran K., Bhattacharya S.Dhanasekharan M, Suppiramaniam V, Prenatal Nicotinic Exposure and Glutamatergic Cholinergic Interplay. SFN 2011, Washington, DC.
  • Bhattacharya S, Buabeid MA, Dwipayan Bhattacharya, Dhanasekaran M, Escobar M., Suppiramaniam V. Investigating memory reconsolidation in fear associated memories, GSC Forum 2014
  • E. Abdel Rahman1, B.Shonesy2, Manal Buabeid, K.Parameshwaran3, M. Ahuja1, M. Dhanasekaran1, R. Judd4, R.Amin1, C.Pinkert3, Y. Tao4, V. Suppiramaniam1. Role of integrins linked kinase in synaptic plasticity and memory. SFN 2011, Washington, DC.
  • Dwipayan Bhattacharya Bhattacharya S, Buabeid MA, Dhanasekaran. Prenatal alcohol impairs synaptic plasticity and memory through ilk pathway in fasd rat model. GSC Forum 2014
  • Manal Buabeid, E. Abdel Rahman1,M. Ahuja1, M. Dhanasekaran1, J. Shen1 ,Y. Tao3, K. Parameshwaran2 V. Suppiramaniam1. Prenatal Nicotine Exposure and Glutamatergic-Cholinergic Interplay. GSC Forum 2013
  • Manuj Ahuja, Manal Buabeid, Engy Abel-Rahman, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran. Neuroprotective effects of Centella asiatica in an Alzheimer’s disease animal model. SFN 2010, Nov. 13-17, 2010, in San Diego, Calif.
  • Manuj Ahuja, Manal Buabeid, Vishnu Suppiramaniam, Muralikrishnan Dhanasekaran. Centella Asiatica an emerging alternative to Alzheimer’s disease. Meeting: SOT 2011, Washington DC, March 6–10, 2011
  • Engy Abdel Rahman, Manal Buabeid, Brian C. Shonesy, Manuj Ahuja, Kodeeswaran Parameshwaran, , Rajesh Amin, Muralikrishnan Dhanasekaran, Carl A. Pinkert, Robert Judd, Yia-Xiong Tao, Vishnu Suppiramaniam. Role of intefrin linked kinase in diabetes induced memory. The 4th annual Boshell Diabetes and Metabolic Diseases Research Day, Auburn University, Auburn Al, 2011.
  • Manuj Ahuja1, Kariharan Thiruchelvam1, Subramanian Uthayathas1, Manal Buabeid, Brown-Borg HM2, Vishnu Suppiramaniam1, Muralikrishnan Dhanasekaran1 .Alterations in the neurochemical pathways contribute to the enhanced memory in long living Ames dwarf mice SFN 2011, Washington, DC.
Memberships, Awards and Honors
  • 2016 Award of best school practicing learning management under my supervision.
  • 2013 Awarded certification of achievement for outstanding poster presentation at Auburn University
  • 2013 Awarded certification of achievement for outstanding from Golden Key International Honor Society, USA
  • 2012 American Federation Pharmaceutical Education (AFPE) Award
  • 2012 Outstanding teaching assistant of Harrison School of Pharmacy
  • Member, Society for Neuroscience.