The purpose was to identify the potential effects for clopidogrel-vonoprazan fumarate interaction. ChemDIS-Mixture was applied for the theoretical assessment of potential outcomes for coexposure of two drugs, vonoprazan fumarate and clopidogrel. This study was executed at low confidence score (0.15). The level of significance for the adjusted p-value is set at 0.05 along with Benjamini-Hochberg multiple test correction. Resultantly, the overlapped disease ontology (DO) terms of stomach disease (DOID: 76), gastritis (DOID: 4029), and peptic ulcer disease (DOID: 750) were identified for vonoprazan fumarate and clopidogrel. The incidence of stomach disease and gastritis were significantly higher (p < 0.05) than the clopidogrel alone. According to these findings, clopidogrel-vonoprazan fumarate interaction may lead to gastric complications.
The purpose was to identify the potential effects for clopidogrel-vonoprazan fumarate interaction. ChemDIS-Mixture was applied for the theoretical assessment of potential outcomes for coexposure of two drugs, vonoprazan fumarate and clopidogrel. This study was executed at low confidence score (0.15). The level of significance for the adjusted p-value is set at 0.05 along with Benjamini-Hochberg multiple test correction. Resultantly, the overlapped disease ontology (DO) terms of stomach disease (DOID: 76), gastritis (DOID: 4029), and peptic ulcer disease (DOID: 750) were identified for vonoprazan fumarate and clopidogrel. The incidence of stomach disease and gastritis were significantly higher (p < 0.05) than the clopidogrel alone. According to these findings, clopidogrel-vonoprazan fumarate interaction may lead to gastric complications.