This is an interdisciplinary, integrated, problem-based module of the reproductive system, comprehensively correlating basic knowledge about the structure and function of the reproductive organs and the breast to clinical manifestations of disease states. Calendar weeks are divided into themes of clinical interest. A PBL case relevant to the theme of the week is discussed and serves to anchor the learning objectives of that theme. The pathogenic origins of disease states of the reproductive system are thoroughly dissected. Students are then provided with the skills and competencies necessary to develop an effective management plan of the common disorders of the male and female reproductive organs. A Clinical Simulation activity runs concurrently, exposing students to real-life clinical scenarios related to the module, and acquainting them with the examination, diagnosis, and management approaches to these clinical presentations.