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Ibrahim Taher Ibrahim El Serafi
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Assistant Professor
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Ext:
5345
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I am an Assistant Professor in the College of Medicine at Ajman University. I teach Biochemistry and Molecular Medicine courses for Foundation, first and third year students. After my graduation from the Faculty of Medicine, Suez Canal University, Egypt; I started both my clinical and teaching career at the department of Medical Biochemistry and Molecular Biology in 2004. After obtaining my Master degree in molecular biology, I moved to Karolinska Institutet for my PhD in January 2010 and defended my thesis at department of Laboratory Medicine. Later, I was intensively involved in clinical practice and teaching for two years at the Faculty of Medicine, Port-Said University, Egypt as an assistant professor of Biochemistry. I joined later on (2017), as a post-doctoral fellow, Linköping University, Sweden and in 2018, I returned to Karolinska Institutet as a post-doctoral fellow then as an assistant professor at department of Oncology-Pathology.
My research experience is placed between the areas of pharmacogenomics, personalized medicine, adoptive T cell therapy and the development of animal models. I also have a vast experience for the development and validation of analytical methods using different analytical techniques.
Education
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PhD, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 2014
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Master degree, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Egypt, 2007
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M.B.B. Ch , Faculty of Medicine, Suez Canal University, Egypt, 2002
Experience
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Assistant professor at Department of Oncology-Pathology, Karolinska Institutet, Sweden, 2019
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Post-doctoral fellow, Department of Oncology-Pathology, Karolinska Institutet, Sweden, 2018
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Post-doctoral fellow, Department of Clinical-Experimental Medicine, Linköping University, Sweden, 2017
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Assistant professor, Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Port-Said University, Egypt, 2015
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Post-doctoral fellow, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 2014
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PhD student, Department of Laboratory Medicine, Karolinska Institutet, Sweden, 2010
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Assistant lecturer at Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Egypt, 2008
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Demonstrator at Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Egypt, 2004
Teaching Area
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Molecular Medicine
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General Chemistry
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Basic Biochemistry
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Clinical Biochemistry
Research
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Adoptive T cell therapy
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Personalized medicine
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Pharmacogenomics
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Hematopoietic stem cell transplantation
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Hematological disorders
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Animal models
Publications
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Journal
Mesothelin-Specific CAR T Cells Target Ovarian Cancer. Esther Schoutrop, Ibrahim El Serafi, Thomas Poiret, Ying Zhao, Okan Gultekin, Rui He, Lidia Moyano-Galceran, Joseph W Carlson, Kaisa Lehti, Moustapha Hassan, Isabelle Magalhaes and Jonas Mattsson. Cancer Research. 2021 June 1. PMID: 33795251, Cancer research, Jun 2021
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Journal
Ahmed El-Serafi, Rui He, Wenyi Zheng, Fadwa Benkossou, Sandra Oerther, Ying Zhao, Karin Mellgren, Britt Gustafsson, Carsten Heilmann, Jukka Kanerva, Kourosh Lotfi, Jacek Toporski, Mikael Sundin, Martin Höglund, Jonas Mattsson, Ibrahim El Serafi and Moustapha Hassan, Vitamin D levels and Busulphan Kinetics in Patients Undergoing Hematopoietic Stem Cell Transplantation, a multicenter study, Bone Marrow Transplantation, Oct 2021
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Journal
Ibrahim El-Serafi, Mats Remberger, Per Ljungman, Olle Ringdèn, Johan Törlen, Mikael Sundin, Andreas Björklund, Jacek Winiarski and Jonas Mattsson, Reduced risk of sinusoidal obstruction syndrome of the liver after Bu-Cy conditioning before allogeneic hematopoietic stem cell transplantation, Clinical and Translational Science, Mar 2020
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Journal
Ibrahim El-Serafi, Orlaith Loy, Ying Zhao, Sandra Oerther and Jonas Mattsson, Pre-formulation investigations for establishing a protocol for treosulfan handling and activation, Pharmaceutical Development and Technology, Jun 2019
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Journal
Ibrahim El-Serafi, Mats Remberger, Ahmed El-Serafi, Fadwa Benkessou, Wenyi Zheng, Eva Martell, Per Ljungman, Jonas Mattsson and Moustapha Hassan, The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after hematopoietic stem cell transplantation, Scientific reports, May 2018
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Journal
Ibrahim El-Serafi, Ylva Terelius, Manuchehr Abedi-Valugerdi, Seán Naughton, Maryam Saghafian, Ali Moshfegh, Jonas Mattsson, Zuzana Potácová and Moustapha Hassan, Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway, PLOS One, Nov 2017
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Journal
Mats Remberger, Johan Törlen, Ibrahim El-Serafi, Karin Garming-Legert, Andreas Björklund, Per Ljungman, Mikael Sundin, Moustapha Hassan and Jonas Mattsson, Toxicological effects of fludarabine and treosulfan conditioning before allogeneic stem-cell transplantation, International Journal of Hematology, Aug 2017
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Journal
Heba Asem, Ying Zhao, Fei Ye, Åsa Barrefelt, Manuchehr Abedi-Valugerdi, Ramy El Sayed, Ibrahim El-Serafi, Svetlana Pavlova, Khalid Abu-Salah, Jörg Hamm, Mamoun Muhammed and Moustapha Hassan, Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging, Journal of Nanobiotechnology, Dec 2016
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Journal
Fadwa Benkessou, Ibrahim El-Serafi, Brigitte Twelkmeyer, Manuchehr Abedi-Valugerdi and Moustapha Hassan, Quantification of Dimethylacetamide and its Primary Metabolite Monomethylacetamide in Plasma Using Robust LC-MS Method, Journal of Analytical & Bioanalytical Techniques, Aug 2016
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Journal
Ibrahim El-Serafi, Parvaneh Afsharian, Ali Moshfegh, Moustapha Hassan and Ylva Terelius, Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation, PLOS One, Nov 2015
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Journal
Ibrahim El-Serafi, Mona Fares, Manuchehr Abedi-Valugerdi, Parvaneh Afsharian, Ali Moshfegh, Ylva Terelius, Zuzana Potácová and Moustapha Hassan, Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies, The Pharmacogenomics Journal, Oct 2015
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Journal
Ibrahim El-Serafi, Tommy Pettersson, Ola Blennow, Jonas Mattsson, Erik Eliasson, Anton Pohanka and Moustapha Hassan, Quantitative method for the determination of posaconazole in mouse organ tissues using liquid chromatography-mass spectrometry, Journal of Analytical & Bioanalytical Techniques, Jun 2014
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Journal
Ola Blennow, Erik Eliasson, Tommy Pettersson, Anton Pohanka, Attila Szakos, Ibrahim El-Serafi, Moustapha Hassan, Olle Ringdén, and Jonas Mattsson, Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation, Antimicrobial Agents and Chemotherapy, Aug 2014
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Journal
Fei Ye, Åsa Barrefelt, Heba Asem, Manuchehr Abedi-Valugerdi, Ibrahim El-Serafi, Maryam Saghafian, Khalid Abu-Salah, Salman Alrokayan, Mamoun Muhammed and Moustapha Hassan, Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging, Biomaterials, Apr 2014
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Journal
Ibrahim El-Serafi, Manuchehr Abedi-Valugerdi, Zuzana Potácová, Parvaneh Afsharian, Jonas Mattsson, Ali Moshfegh and Moustapha Hassan, Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation, PLOS One, Jan 2014
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Journal
Fredrik Sjöö, Ibrahim El-Serafi, Jon Enestig, Jonas Mattsson, Johan Liwing and Moustapha Hassan, Comparison of algorithms for oral busulphan area under the concentration-time curve limited sampling estimate, Clinical Drug Investigation, Nov 2013
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Journal
Hatem Sallam, Ibrahim El-Serafi, Laurent Meijer and Moustapha Hassan, Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice, BMC Pharmacology and Toxicology, Sep 2013
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Journal
Ibrahim El-Serafi, Ylva Terelius, Brigitte Twelkmeyer, Ann-Louise Hagbjörk, Zuzana Hassan and Moustapha Hassan, Gas chromatographic- Mass spectrometry method for the detection of busulphan and its metabolites in plasma and urine, Journal of Chromatography B, Jan 2013
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Journal
Taher I. EL Serafi, Emad F. Ismail, Moushira A. Mahmoud, Nagwan A. Mohamed, Maivel H. Ghattas, Hanan S. Mohamed, Dahlia I. Badran and Ibrahim El-Serafi, Effect alpha globlin gene deletion and gamma globin gene-158 (c/t) polymorphism in beta-thalassemic patients, Egyptian Journal of Biochemistry & Molecular Biology, Dec 2008
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Journal
Ahmed A Nugud, Ibrahim El-Serafi and Ahmed T El-Serafi, Three-dimensional culturing models for bone development, Advances in Tissue Engineering and Regenerative Medicine, Dec 2018
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Journal
Ahmed El-Serafi, Ibrahim El-Serafi, Moustafa Elmasry, Ingrid Steinvall and Folke Sjoberg, Skin Regeneration in Three Dimensions, Current Status, Challenges and Opportunities, Differentiation, Jun 2017
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Journal
Nikolai Zhelev, Dimitar Trifonov, Shudong Wang, Moustapha Hassan, Ibrahim El-Serafi and Vanio Mitev, From Roscovitine to CYC202 to Seliciclib–from bench to bedside: discovery and development, BioDiscovery, Dec 2013
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Book Chapter
The potentiality of histone deacetylase inhibitors for diabetes and obesity, Histone modifications in therapy, Translational Epigenetics Series, Elsevier
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Book Chapter
Busulphan metabolic pathway and possible drug interactions, Horizons in Cancer Research, Nova Science
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Journal
Ahmed Nugud, Latifa Alghfeli, Moustafa Elmasry, Ibrahim El-Serafi and Ahmed T. El-Serafi, Biomaterials as a Vital Frontier for Stem Cell-Based Tissue Regeneration., Frontiers in Cell and Developmental Biology, Mar 2022
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Journal
Ibrahim El-Serafi, Sandra Oerther, Ying Zhao and Moustapha Hassan, The Role of Cytochrome P450 2J2 in Cancer: Cell Protector, Therapeutic Target, or Prognostic Marker?, OBM Transplantation, Jul 2022
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Journal
Ahmed T El-Serafi*, Ibrahim El-Serafi*, Ingrid Steinvall, Folke Sjöberg and Moustafa Elmasry, A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective., International Journal of Molecular Science, Jul 2022
Conference Presentation
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Characterization of MSLN CAR T-cells in an ovarian cancer model; poster presentation at Frontiers in Cancer Research and Therapy. 2018, March 8-9, Stockholm, Sweden.
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Vitamin D Relation to Busulphan in Pediatrics Undergoing Hematopoietic Stem Cell Transplantation; abstract at The American Society of Hematology (ASH) 59th Annual Meeting and Exposition. 2017, December 9-12, Atlanta, GA, USA.
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Biodistribution of busulphan metabolites and their effect on central nervous system; poster presentation at the 23rd Mayo Clinic-Karolinska Institutet Annual Scientific Research Meeting. 2017, September 7-8, Stockholm, Sweden.
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Toxicological side-effects of Fludarabin and Treosulfan conditioning before allogeneic stem-cell transplantation; poster presentation at the 43rd Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT). 2017, March 26-29, Marseille, France.
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Towards personalized medicine on pharmacogenomics basis; oral presentation at the 1st annual conference of the Faculty of Medicine, Port-Said University. 2016, March 24-25, Port-Said, Egypt.
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The importance of pharmacogenomics in personalized conditioning regimen prior to stem cell transplantation; oral presentation at the 1st annual biomedical conference, Recent advances in stem cell research, Faculty of Medicine, Suez Canal University. 2015, October 29-30, Ismailia, Egypt.
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Busulphan Metabolism Via Flavin-Containing Monooxygenase 3 (FMO3) Can Explain Several Interactions with Other Drugs; poster presentation at the 56th American Society of Hematology (ASH) annual Meeting and exposition. December 6-9 2014, San Francisco, CA, USA.
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The role of CYP2J2 in cyclophosphamide metabolism; poster presentation at the 18th congress of the European Hematology Association (EHA). 2013, June 13 16, Stockholm, Sweden.
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Microbubbles and microcapsules as drug delivery vehicles for chemotherapy; poster presentation at Label-Free Technologies Conference, Advances and Applications. 2012, November 1-3, Amsterdam, Netherlands.
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The role of human CYP2B6 polymorphism and reductase on bioactivation of cyclophosphamide; invited speaker at the 17th congress of the European Hematology Association (EHA). 2012, June 14-18, Amsterdam, Netherlands.
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Molecular analysis of the possible mutations in the gamma globin gene in patients with beta thalassemia in Suez Canal Region; oral presentation at the 5th Scientific Congress of Clinical Pathology Department, Faculty of Medicine, Suez Canal University. 2007, May, Ismailia, Egypt.
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Tumor tailored lymphodepletion and CAR T-cell functionality in advanced ovarian cancer; poster presentation at 2nd Translational Research Conference Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells”, organized by The European School of Hematology (ESH). 2022, September 12-14, Berlin, Germany
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Mesothelin Directed Chimeric Antigen Receptor T Cell Therapy for Treatment of Advanced Ovarian Cancer; poster presentation at The International Conference Immune and Cellular Therapies: Focus on Immune Based Therapeutic Concepts”, organized by The European School of Hematology (ESH). 2019, September 20-22, Mandelieu, France.
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Immunotherapy for cancer treatment; plenary speaker at Recent Advances in Molecular and Cellular Medicine, the Center of Excellence in Molecular and Cellular Medicine second annual conference, Faculty of Medicine, Suez Canal University. 2018, December 26-27, Ismailia, Egypt.
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The Establishment of Ovarian Cancer Mouse Model for The Evaluation of MSLN CAR T-cells; oral presentation at Kick-Off 2018, Oncology-Pathology department, Karolinska Institutet. 2018, August 29th, Stockholm, Sweden.
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Reduced risk of sinusoidal obstruction syndrome of the liver after Bu-Cy conditioning before allogeneic hematopoietic stem cell transplantation, a result of personalized dose adjustment; abstract at the 23rd congress of the European Hematology Association (EHA). 2018, June 14-17, Stockholm, Sweden.
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Pre-analytical investigations for establishing a protocol for treosulfan handling and activation; abstract at the 23rd congress of the European Hematology Association (EHA). 2018, June 14-17, Stockholm, Sweden.
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The effect of N-acetyl-l-cysteine (NAC) on liver toxicity and clinical outcome after hematopoietic stem cell transplantation; oral presentation at The International Hematologists Summit. 2018, May 21-22, Valencia, Spain.
Memberships, Awards and Honors
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Declaration of Honor from the Center of Excellence in Molecular and Cellular Medicine, Faculty of Medicine, Suez Canal University, Egypt, 2018
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European Hematology Association (EHA), 2012
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Swedish Medical Association (SLS), 2017