This course is designed to give the student basic concepts of toxicology as they apply to the effects of environmental agents, e.g. chemicals, metals, on human health. The course discusses the distribution, cellular penetration, metabolic conversion, and elimination of toxic agents, as well as the fundamental laws governing the interaction of foreign chemicals with biological systems to cause adverse effects. The lecture course provides students with a conceptual framework for understanding the broad spectrum of Clinical toxicology of drugs and essential chemicals, (toxic dose, diagnosis and treatment with focus on antidotes and, the basic principles and mechanisms of toxicology as applied to various chemicals or classes of chemicals in selected tissues and organs.