-
Akram Ashour Ashames
- Associate Professor, Assistant Vice Chancellor for Academic Affairs
- Ext: 5202
Dr. Akram Ashour Ashames has over 25 years of proven experience in university teaching and research at both undergraduate and graduate levels, specializing in pharmaceutical sciences, with a focus on drug delivery, nanoformulations, and nanobiomaterial separation and characterization. He possesses extensive hands-on experience in drug delivery development, pharmaceutical quality control, and quality assurance, alongside proficiency in pharmaceutical analytical methods and laboratory management. Additionally, Dr. Ashames is skilled in developing and implementing pharmacy-based policies and has a strong background in pharmaceutical policy development and execution.
Education
- PhD, Materials Science (Nanobiomaterial Separation & Characterization), Colorado School of Mines, USA, 2015
- MSc, Materials Science (Nanobiomaterial Separation & Characterization), Colorado School of Mines, USA, 2011
- MS, Pharmaceutical Industry Management, Burgundy School of Business, France, 2003
- B.Pharm, University of Tripoli, Libya, 1994
PhD, Materials Science (Nanobiomaterial Separation & Characterization), Colorado School of Mines, USA, 2015
MSc, Materials Science (Nanobiomaterial Separation & Characterization), Colorado School of Mines, USA, 2011
MS, Pharmaceutical Industry Management, Burgundy School of Business, France, 2003
B.Pharm, University of Tripoli, Libya, 1994
Experience
- Assistant Vice Chancellor for Academic Affairs (AVCAA), Ajman University, UAE, 2022-Present
- Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2026-Present
- Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2020-2026
- Head of Laboratories, College of Pharmacy & Health Sciences, Ajman University, 2017-Present
- Chair, Council for Advising, Registration and Enrollment (CARE), Ajman University, UAE, 2022-Present
- Head of Pharmaceutical Chemistry & Pharmacognosy Department, College of Pharmacy & Health Sciences, Ajman University, UAE, 2016-2017
- Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2016-2020
- Assistant Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Libya, 2015-2016
- Visiting Assistant Professor, Faculty of Pharmacy, Almerghab University, Libya, 2015-2016
- Teaching Assistant, Department of Chemistry, Colorado School of Mines, USA, 2012-2013
- Head of Quality Assurance Department, Faculty of Pharmacy, University of Tripoli, Libya, 2016
- General Manager of State Pharmaceutical Quality Control Administration (Libyan FDA), Libya, 2005-2006
Assistant Vice Chancellor for Academic Affairs (AVCAA), Ajman University, UAE, 2022-Present
Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2026-Present
Associate Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2020-2026
Head of Laboratories, College of Pharmacy & Health Sciences, Ajman University, 2017-Present
Chair, Council for Advising, Registration and Enrollment (CARE), Ajman University, UAE, 2022-Present
Head of Pharmaceutical Chemistry & Pharmacognosy Department, College of Pharmacy & Health Sciences, Ajman University, UAE, 2016-2017
Assistant Professor, Department of Pharmaceutical Sciences, College of Pharmacy & Health Sciences, Ajman University, 2016-2020
Assistant Professor, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tripoli, Libya, 2015-2016
Visiting Assistant Professor, Faculty of Pharmacy, Almerghab University, Libya, 2015-2016
Teaching Assistant, Department of Chemistry, Colorado School of Mines, USA, 2012-2013
Head of Quality Assurance Department, Faculty of Pharmacy, University of Tripoli, Libya, 2016
General Manager of State Pharmaceutical Quality Control Administration (Libyan FDA), Libya, 2005-2006
Teaching Area
- Pharmaceutical Analysis and Quality Control
- Pharmaceutical Quality Assurance
- Pharmaceutical Management
- Pharmaceutical Regulatory Affairs
Pharmaceutical Analysis and Quality Control
Pharmaceutical Quality Assurance
Pharmaceutical Management
Pharmaceutical Regulatory Affairs
Research
- Nanobiomaterial separation and characterization
- Pharmaceutical counterfeiting
- Method development and validation for pharmaceutical analysis
Nanobiomaterial separation and characterization
Pharmaceutical counterfeiting
Method development and validation for pharmaceutical analysis
Publications
-
JournalMuna Barakat, Juhaina M Abu Ershaid, Lujain F Alzaghari, Shaymaa B Abdulrazzaq, Daniah Raad, Eliza Hasen, Raja’a A Al-Qudah, Dinesh Kumar Chellappan, Tamara Athamneh, Mohammad AA Al-Najjar, Akram Ashames, How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases, International Journal of Nanomedicine, Jan 2026, doi: https://doi.org/10.2147/IJN.S562959
-
JournalTahneem Yaseen, Muhammad Umair Afzal, Mustafa A Alhamaidah, Amer Hayat Khan, Musarrat Rrauf Burki, Mudassar Iqbal Arain, Akram A Ashames, Pooled frequency of ceftriaxone-induced urolithiasis in pediatric patients: a systematic review and meta-analysis, Pediatric Nephrology, Jun 2026, doi: https://doi.org/10.1007/s00467-026-07358-8
-
JournalGhaseb N Makhadmeh, Abdulsalam Abuelsamen, Mahmoud Al-Gharram, Akram Ashames, Samer H Zyoud, M-Ali H Al-Akhras, Khaled Aljarrah, Mohamed Abdelfattah, Omar Mouhtady, Tariq AlZoubi, Optimized Talaporfin-Encapsulated by Silica Nanoparticles for In-Vitro Photodynamic Therapy Against MCF-7 Cancer Cells, Chemical Physics Impact, Mar 2026, doi: https://doi.org/10.1016/j.chphi.2026.101048
-
JournalNoor Kamal Raisan, Moawia M Al-Tabakha, Akram Ashames, Evaluating community pharmacists’ dispensing and counseling practices of semaglutide for weight loss in the United Arab Emirates: A simulated patient study, Pharmacy Practice, Mar 2026, doi: https://doi.org/10.18549/PharmPract.2026.1.3476
-
JournalKhaled Aljarrah, M-Ali H Al-Akhras, Ghaseb Makhadmeh, Abdulsalam Abuelsamen, Mahmoud Al Gharram, Samer Zyoud, Akram Ashames, Tariq AlZoubi, Enhancing Photodynamic Therapy via Encapsulated Temoporfin by Silica Nanoparticles: A Red Blood Cell–Based Efficacy and Modeling Study, Photodiagnosis and Photodynamic Therapy, Feb 2026, doi: https://doi.org/10.1016/j.pdpdt.2026.105391
-
JournalAkram Ashames, Saleha Anwar, Md Nayab Sulaimani, Pinky, Mohd Shahnawaz Khan, Moyad Shahwan, Suhel Parvez, Md Imtaiyaz Hassan, Khuzin Dinislam, Anas Shamsi, Targeting cancer metabolism through p-cresol mediated Inhibition of pyruvate dehydrogenase kinase 3 in lung cancer, Scientific Reports, Nov 2025, doi: https://doi.org/10.1038/s41598-025-25246-3
-
JournalAnas Shamsi, Nojood Altwaijry, Moyad Shahwan, Akram Ashames, Dharmendra Kumar Yadav, Mohammad Furkan, Rizwan Hasan Khan, Identification of potential inhibitors of Ubiquitin carboxyl-terminal hydrolase 21 from repurposed drugs: Implications in anticancer therapeutics, Chemical Physics Impact, Jun 2025, doi: https://doi.org/10.1016/j.chphi.2024.100792
-
JournalZehra Edis, Samir Haj Bloukh, Akram Ashames, Moawia M Al-Tabakha, Moyad JSA Shahwan, Hamed Abu Sara, Sai HS Boddu, Sohaib N Khan, Ibrahim Haj Bloukh, Maram Eladdasy, Somayeh Sadeghi, Haneen Abdulmalek Alkubaisi, Iman Haj Bloukh, Nageeb AGM Hassan, Syzygium aromaticum extract mediated, sustainable Silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities, Frontiers in Chemistry, Jan 2025, doi: https://doi.org/10.3389/fchem.2024.1513150
-
JournalSamer H Zyoud, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S Yahia, Ahed H Zyoud, Heba Y Zahran, Naser Qamhieh, Ghaseb N Makhadmeh, Tariq AlZoubi, Superior photocatalytic degradation of pharmaceuticals and antimicrobial Features of iron-doped zinc oxide sub-microparticles synthesized via laser-assisted chemical bath technique, Results in Engineering, Dec 2024, doi: https://doi.org/10.1016/j.rineng.2024.102875
-
JournalSamer H Zyoud, Samer O Alalalmeh, Omar E Hegazi, Jamil H Alami, Che Azurahanim Che Abdullah, IS Yahia, Nageeb Hassan, Akram Ashames, HY Zahran, Samir Haj Bloukh, Moyad Shahwan, Ahed H Zyoud, Ammar Abdulrahman Jairoun, Naser Qamhieh, Exploration of laser-assisted chemical bath for enhancing synthesis of undoped and nickel-doped zinc oxide and its potential applications in water purification and mitigating antimicrobial resistance, Optik, 315, Sep 2024, doi: https://doi.org/10.1016/j.ijleo.2024.172046
-
JournalSamer H. Zyoud, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S. Yahia, Ahed H. Zyoud, Heba Y. Zahran, Naser Qamhieh, Ghaseb N. Makhadmeh, Tariq AlZoubi, Superior photocatalytic degradation of pharmaceuticals and antimicrobial Features of iron-doped zinc oxide sub-microparticles synthesized via laser-assisted chemical bath technique, Results in Engineering, 24, Sep 2024, doi: 10.1016/j.rineng.2024.102875
-
JournalSamer H Zyoud, Akram Ashames, Ahed H Zyoud, Anupama R Prasad, Che Azurahanim Che Abdullah, Shaher H Zyoud, Ibrahim S Yahia, Ghaseb N Makhadmeh, Awais Khalid, Naser Qamhieh, Heba Y Zahran, Sani Muhammad, Mohamed Sh Abdel-wahab, Advanced photodegradation and antimicrobial performance: A comparative study of Al/Ag-Co-doped ZnO synthesis via laser assist chemical bath, Materials Science and Engineering: B, 309, pp.117649 - , Nov 2024, doi: 10.1016/j.mseb.2024.117649
-
JournalAnas Shamsi, Moyad Shahwan, Saleha Anwar, Akram Ashames, Mohd Shahnawaz Khan & Dharmendra Kumar Yadav , Understanding the interactions between repurposed drugs sertindole and temoporfin with receptor for advanced glycation endproducts: Therapeutic implications in cancer and metabolic diseases, Journal of Molecular Modeling, 30, pp.170 - , May 2024, doi: https://doi.org/10.1007/s00894-024-05967-4
-
JournalIhsan Ali Mahar, Aneela Tahira, Mehnaz Parveen, Ahmed Ali Hulio, Zahoor Ahmed Ibupoto, Muhammad Ali Bhatti, Elmuez Dawi, Ayman Nafady, Riyadh H Alshammari, Brigitte Vigolo, Kezhen Qi, Elfatih Mustafa, Lama Saleem, Akram Ashames, Zafar Hussain Ibupoto, Glucose sensing via green synthesis of NiO–SiO2 composites with citrus lemon peel extract, Journal of Materials Science: Materials in Electronics, 35, pp.490 - , Mar 2024, doi: 10.1007/s10854-024-12156-9
-
JournalAkram Ashames, Munaza Ijaz, Manal Buabeid, Haya Yasin, Sidra Yaseen, Richie R. Bhandare, Ghulam Murtaza , In Vivo Wound Healing Potential and Molecular Pathways of Amniotic Fluid and Moringa Olifera-Loaded Nanoclay Films, Molecules, 29, pp.729 - , Feb 2024, doi: 10.3390/molecules29030729
-
JournalAdeel Liaquat Bhatti, Aneela Tahira, Imran Ali Halepoto, Shusheel Kumar, Zaheer Ahmed Ujjan, Ayman Nafady, Nemah Abu Shama, Elmuez Dawi, Akram Ashames, Lama Saleem, Matteo Tonezzer, Antonia Infantes-Molin & Zafar Hussain Ibupoto , Green-Mediated Synthesis of Co3O4 Nanostructures for Efficient Oxygen Evolution Reaction and Supercapacitor Applications, Journal of Electronic Materials, 53, pp.1012 - 1025, Feb 2024, doi: https://doi.org/10.1007/s11664-023-10846-4
-
JournalSamer H. Zyoud, Bayan M. Al Radi, Bashayer M. Al Maamari, Mohamed Nasor, H. Y. Zahran, I. S. Yahia, Taimoor Ahmad, Sohaib N. Khan, Ahed H. Zyoud, Moyad Shahwan, Nageeb Hassan, Akram Ashames, Malek G. Daher, Ghaseb N. Makhadmeh, Naser Qamhieh, Ammar Abdulrahman Jairoun & Mohamed Sh. Abdel-wahab , Efficient Al-doped ZnO nanostructured synthesis by laser-assisted chemical bath: structural, optical, and photocatalytic activity using blue laser irradiation, Indian Journal of Physics, 98, pp.549 - 560, Feb 2024, doi: https://doi.org/10.1007/s12648-023-02828-3
-
JournalSamer H. Zyoud, Omar E. Hegazi, Samer O. Alalalmeh, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S. Yahia, Ahed H. Zyoud, Malek G. Daher, Moyad Shahwan, Samir Haj Bloukh, Heba Y. Zahran, Naser Qamhieh, Mohamed Nasor, Ammar Jairoun , Enhancing Antimicrobial and Photocatalyst Properties of Mg-Doped ZnO Nanotubes via a Novel Laser-Assisted Chemical Bath Synthesis, Journal of Saudi Chemical Society, Oct 2023, doi: 10.1016/j.jscs.2023.101752
-
JournalSamer H Zyoud, Omar E Hegazi, Samer O Alalalmeh, IS Yahia, HY Zahran, Samir Haj Bloukh, Hamed Abu Sara, Ahed H Zyoud, Moyad Shahwan, Akram Ashames, Nageeb Hassan, Malek G Daher, Ghaseb N Makhadmeh, Ammar Abdulrahman Jairoun, Elbadawy A Kamoun, Enhanced photocatalytic and antimicrobial properties of undoped and aluminum-doped zinc oxide nanosheets synthesized via novel laser-assisted chemical bath technique, Applied Physics A, 129, Oct 2023, doi: https://doi.org/10.1007/s00339-023-07033-x
-
JournalKarim Kakaei, Mohsen Padervand, Yuksel Akinay, Elmuez Dawi, Akram Ashames, Lama Saleem, Chuanyi Wang, A critical mini-review on challenge of gaseous O 3 toward removal of viral bioaerosols from indoor air based on collision theory, Environmental Science and Pollution Research, Jun 2023, doi: http://dx.doi.org/10.1007/s11356-023-28402-2
-
JournalMoyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Atiya Akhtar, PF543-like compound, a promising sphingosine kinase 1 inhibitor: Structure-based virtual screening and molecular dynamic simulation approaches, International Journal of Biological Macromolecules, 245, Jun 2023, doi: 10.1016/j.ijbiomac.2023.125466
-
JournalSakineh Fotouhi, Maher Assaad, Mohamed Nasor, Ahmed Imran, Akram Ashames and Mohammad Fotouhi, Multivariable Signal Processing for Characterization of Failure Modes in Thin-Ply Hybrid Laminates Using Acoustic Emission Sensors, Sensors, 23, pp.5244 - , May 2023, doi: 10.3390/s23115244
-
JournalE. A. Dawi, E. Mustafa, M. Padervand, A. Ashames, S. Hajiahmadi, L. Saleem, M. Baghernejad, O. Nur & M. Willander , Ag/AgCl Decorated Ionic Liquid@Tantalum Pentoxide Nanostructures: Fabrication, Photocatalytic Activity, and Cytotoxicity Effects Against Human Brain Tumor Cells, Journal of Inorganic and Organometallic Polymers and Materials, May 2023, doi: https://doi.org/10.1007/s10904-023-02693-x
-
JournalSamer H. Zyoud, Samer O. Alalalmeh, Omar E. Hegazi, Ibrahim S. Yahia, Heba Y. Zahran, Hamed Abu Sara, Samir Haj Bloukh, Moyad Shahwan, Ahed H. Zyoud, Nageeb Hassan, Akram Ashames, Malek G. Daher, Ghaseb N. Makhadmeh, Ammar Jairoun, Naser Qamhieh, and Mohamed Sh. Abdel-wahab, Novel Laser-Assisted Chemical Bath Synthesis of Pure and Silver-Doped Zinc Oxide Nanoparticles with Improved Antimicrobial and Photocatalytic Properties, Catalysts, 13, pp.900 - 923, May 2023, doi: 10.3390/catal13050900
-
JournalSumaiya Kifayat, Vidyasrilekha Yele, Akram Ashames, Dilep Kumar Sigalapalli, Richie R. Bhandare, Afzal B. Shaik, Venkatarathnam Nasipireddyg and Bharat Kumar Reddy Sanapalli , Filamentous temperature sensitive mutant Z: a putative target to combat antibacterial resistance, RSC Advances, 13, pp.11368 - 11384, Apr 2023, doi: https://doi.org/10.1039/D3RA00013C
-
JournalSamer H. Zyoud, Ibrahim S. Yahia, Moyad Shahwan, Ahed H. Zyoud, Heba Y. Zahran, Mohamed Sh. Abdel-wahab, Malek G. Daher, Mohamed Nasor, Ghaseb N. Makhadmeh, Nageeb Hassan, Akram Ashames, Naser Qamhieh , Fast and Excellent Enhanced Photocatalytic Degradation of Methylene Blue Using Silver-Doped Zinc Oxide Submicron Structures under Blue Laser Irradiation, Crystals, 13, pp.229 - , Jan 2023, doi: https://doi.org/10.3390/cryst13020229
-
JournalJada Naga Lakshmi, Ankem Narendra Babu, S. S. Mani Kiran, Lakshmi Prasanthi Nori, Nageeb Hassan, Akram Ashames, Richie R. Bhandare, Afzal B. Shaik, Herbs as a Source for the Treatment of Polycystic Ovarian Syndrome: A Systematic Review, BioTech, 12, pp.4 - , Jan 2023, doi: 10.3390/biotech12010004
-
JournalMustafa Ameen AlHamaidah, Noora Noureldin, Adham Yehia, Ibrahim Alani, Abdelaziz Al-Qussain, Osama Abdou, Akram Ashames, Zelal Kharaba , Efficacy and Short-Term Safety of COVID-19 Vaccines: A Cross-Sectional Study on Vaccinated People in the UAE, Vaccines, 10, pp.2157 - , Dec 2022, doi: https://doi.org/10.3390/vaccines10122157
-
JournalBharat Kumar Reddy Sanapalli, Akram Ashames, Dilep Kumar Sigalapalli, Afzal B Shaik, Richie R Bhandare, Vidyasrilekha Yele, Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review, Antibiotics, 11, pp.1680 - , Nov 2022, doi: 10.3390/antibiotics11121680
-
JournalAkram Ashames, Fahad Pervaiz, Moawia Al-Tabakha, Kanza Khalid, Nageeb Hassan, Hina Shoukat, Manal Buabeid, Ghulam Murtaza, Synthesis of Cross-linked Carboxymethyl Cellulose and Poly (2-Acrylamido-2-methylpropane Sulfonic Acid) Hydrogel for Sustained Drug Release Optimized by Box-Behnken Design, Journal of Saudi Chemical Society, Sep 2022, doi: 10.1016/j.jscs.2022.101541
-
JournalAkram Ashames, Kaleem Ullah, Moawia Al-Tabakha, Shujaat Ali Khan, Nageeb Hassan, Abdul Mannan, Muhammad Ikram, Manal Buabeid, Ghulam Murtaza , Development, characterization and In-vitro evaluation of guar gum based new polymeric matrices for controlled delivery using metformin HCl as model drug, Plos One, 17, pp.e0271623 - , Jul 2022, doi: 10.1371/journal.pone.0271623
-
JournalUrooj Afreen, Khairi Mustafa Fahelelbom, Syed Nisar Hussain Shah, Akram Ashames, Uzma Almas, Shujaat Ali Khan, Muhammad Arfat Yameen, Naveed Nisar, Muhammad Hassham Hassan Bin Asad, Ghulam Murtaza , Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy, Journal of Experimental Nanoscience, 17, pp.467 - 495, Jul 2022, doi: 10.1080/17458080.2022.2094915
-
JournalBadriyah Shadid Alotaibi, Akram Ashames, Manal Buabeid, Momina Masood, Sadullah Mir, Ghulam Murtaza, A new approach for the management of Escherichia coli and Klebsiella pneumonia by using cefixime-based bionanocomposite films, Journal of Experimental Nanoscience, 1, pp.389 - 419, Jun 2022, doi: 10.1080/17458080.2022.2080197
-
JournalZeeshan Patel, Sankalp Gharat, Anita D. Chando, Munira Momin, Moawia M. Al-Tabakha, Akram Ashames, Sai HS. Boddu, Recent advancements in Electrospun Nanofibers for Wound Healing: Polymers, Clinical and Regulatory Perspective, Critical Reviews in Therapeutic Drug Carrier Systems, 39, Jan 2022
-
JournalKhairi Mustafa Fahelelbom, Abdullah Saleh, Moawia M. A. Al-Tabakha and Akram A. Ashames, Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review, Reviews in Analytical Chemistry, 41, pp.21 - 33, Jan 2022, doi: https://doi.org/10.1515/revac-2022-0030
-
JournalWlla Wail Al-Halbouni, Moawia M Altabakha, Akram A Ashames, Adi I Arida, Muaed J Alomar, Osteosarcoma Occurrence in Preclinical and Clinical Experiments with Teriparatide: A Qualitative Review, Thai Journal of Pharmaceutical Sciences (TJPS), 46, pp.120 - 126, Mar 2022
-
Badriyah Shadid Alotaibi, Fahad Pervaiz, Manal Buabeid, Akram Ashames, Khairi Mustafa Fahelelbom, Sana Siddique, Hina Shoukat, Sadia Rehman, Sobia Noreen, Ghulam Murtaza. Nanostructured Lipid Carriers Based Suppository for Enhanced Rectal Absorption of Ondansetron: In vitro and In vivo Evaluations. Arabian Journal of Chemistry, 14(12) 103426 (2021)
-
Ameena Asheq, Akram Ashames, Moawia Al-Tabakha, Nageeb Hassan, Ammar Jairoun. Medication adherence in type 2 diabetes mellitus patients during Covid-19 pandemic: a cross-sectional study from the United Arab Emirates. F1000Research, 10, 435 (2021)
-
Sobia Noreen, Fahad Pervaiz, Akram Ashames, Manal Buabeid, Khairi Fahelelbom, Hina Shoukat, Irsah Maqbool, Ghulam Murtaza. Optimization of Novel Naproxen-Loaded Chitosan/Carrageenan Nanocarrier-Based Gel for Topical Delivery: Ex Vivo, Histopathological, and In Vivo Evaluation. Pharmaceuticals, 14(6), 557 (2021)
-
Moawia M. Al-Tabakha, Shujaat Ali Khan, Akram Ashames, Hamid Ullah, Kaleem Ullah, Ghulam Murtaza, Nageeb Hassan. Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir. Pharmaceuticals, 14(3), 234 (2021)
-
Subish Palaian, Manal Buabeid, Akram Ashames. Patient Safety Culture in Handling Prescriptions and Interprofessional Collaboration Practices Amongst Community Pharmacists: An Investigative Simulated Patient Study from the United Arab Emirates. Risk Management and Healthcare Policy, 13, 3201—3209 (2020)
-
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sa’ed H Zyoud, Akram Ashames. Hidden Formaldehyde Content in Cosmeceuticals Containing Preservatives that Release Formaldehyde and Their Compliance Behaviors: Bridging the Gap between Compliance and Local Regulation. Cosmetics, 7(4), 93 (2020)
-
Richie Bhandare, Vaishali Londhe, Akram Ashames, Nadeem Shaikh, Sham Zain Alabdin. Enhanced Solubility of Microwave-assisted Synthesized Acyclovir Co-crystals. Research Journal of Pharmacy and Technology, 13, 12, 5979-5986 (2020)
-
Sai HS Boddu, Diwakar B Tukaramrao, Moawia M Al-Tabakha, Akram Ashames, Rabin Neupane, R Jayachandra Babu, Jwala Renukuntla, Amit K Tiwari, Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection. Pharmaceuticals, 13, 11, 253 (2020)
-
Shujaat Ali Khan, Wajeeha Azam, Akram Ashames, Khairi Mustafa Fahelelbom, Kaleem Ullah, Abdul Mannan, Ghulam Murtaza. β-Cyclodextrin-based (IA-co-AMPS) Semi-IPNs as Smart Biomaterials for Oral Delivery of Hydrophilic Drugs: Synthesis, Characterization, In-Vitro and In-Vivo Evaluation. Journal of Drug Delivery Science and Technology, 60, (2020), 101970
-
Ashames et al, Pharmaceutical Quality Attributes of Various Brands of Metformin Hydrochloride Tablets from UAE Market Including Recently Recalled Products. Research Journal of Pharmacy and Technology;14(2) (2021), Accepted
-
Jianxian Chen, Akram Ashames, Manal Ali Buabeid, Khairi Mustafa Fahelelbom, Muhammad Ijaz, Ghulam Murtazad. Nanocomposites drug delivery systems for the healing of bone fractures. International Journal of Pharmaceutics; 585, 119477 (2020)
-
Ashames et al, Development and Ex-Vivo Skin Permeation Studies of Finasteride-PLGA and Minoxidil- Chitosan Nanoparticulate Systems. Journal of Bioactive and Compatible Polymers, 35 (2), 77-91 (2020)
-
A Shah, AA Ashames, MA Buabeid, G Murtaza. Synthesis, in vitro characterization and antibacterial efficacy of moxifloxacin-loaded chitosan-pullulan-silver-nanocomposite films. Journal of Drug Delivery Science and Technology, 55, 101366 (2020)
-
May Reda, Akram Ashames, Zehra Edis, Samir Bloukh, Richie Bhandare, Hamed Abu Sara. Green synthesis of potent antimicrobial silver nanoparticles using different plant extracts and their mixtures. Processes 7 (8), 510 (2019)
-
Akram Ashames. Bachelor of Pharmacy Programs in United Arab Emirates. Universal Journal of Educational Research 7 (8), 1650-1662 (2019)
-
Akram Ashames, Richie Bhandare, Sham Zain AlAbdin, Tasnim Alhalabi, Farah Jassem. Public perception toward e-commerce of medicines and comparative pharmaceutical quality assessment study of two different products of furosemide tablets from community and illicit online pharmacies. Journal of Pharmacy And Bioallied Sciences 11(3), 284 (2019)
-
Akram Ashames, Nageeb Hassan, Kristen Alamir, Kamar Modalaleh, Alin Naser, Aya Khawatmi. Correlation between Neck Circumference, Waist Circumference, Body Mass Index, and Overweight/Obesity among Ajman University Students, Research J. Pharm. and Tech. 12(5), 2443-2452 (2019)
-
Akram Ashames, Richie Bhandare, Sham Zain AlAbdin, Amna Aljashamy, Aya Atfeh, Abir Elwaer, Noura Fakhry. In vitro Comparative Quality Attributes of Selected Brands of Fexofenadine Hydrochloride Tablets Marketed in UAE and India. Book title: Chemistry for a Clean and Healthy Planet (Chapter 5), Springer, September 2019)
-
Zehra Edis, Samir Haj Bloukh, Akram Ashames, May Ibrahim. Copper-based nanoparticles, their chemistry and antibacterial properties: A Review. Book title: Chemistry for a Clean and Healthy Planet (Chapter 24), Springer, September 2019)
-
Akram Ashames, Sham Zain AlAbdin, Fatima ElZahra ElMahdi, Asma Samhi, Manar Farraj. Qualitative and quantitative characterization of hazardous triclosan traces in household personal care soaps marketed in UAE. Journal of Pharmaceutical Sciences and Research,11 (1), 89-92 (2019).
-
Akram Ashames, Moawia M. Al-Tabakha, Sham Zain AlAbdin, Zainab Ahmad. Tablet Splitting: Public Perception and Quality Attributes of Two Common Cardiovascular Drugs. Research Journal of Pharmacy and Technology, 11, (12), 5562-5568 (2018).
-
Heena D. Patel, Moayad Al Shahwan, Akram Ashames, Mohammed Waseemul Islam, Richie Bhandare. One pot microwave-assisted synthesis of 3-benzyl-5hydroxymethyl-1,3-oxazolidin-2-one. Journal of Pharmaceutical Sciences and Research, 10 (11), 2814-281 (2018).
-
Amal Ammar, Mohamed El-Attug, Amal Belaid, Sakina Sadaawi, Ruwida Kamour, Akram Ashames, Tariq Almog and Shukri Alsharif. Separation of complexed semi-synthetic flavonoids by using fused core column in short time. Journal of Chemical and Pharmaceutical Research 8 (3), 438-443 (2016).
-
S. Kim Williams Ratanathanawongs, J. Ray Runyon, Akram A. Ashames. Field-Flow Fractionation: Addressing the Nano Challenge. Anal. Chem., 83 (3), 634–642 (2011).
-
S. Kim Williams Ratanathanawongs, Marie-Anna Benincasa, Akram A. Ashames. Field-Flow Fractionation in Analysis of Polymers and Rubbers. Encyclopedia of Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester. DOI:10.1002/9780470027318.a2008.pub2 (2009).
Muna Barakat, Juhaina M Abu Ershaid, Lujain F Alzaghari, Shaymaa B Abdulrazzaq, Daniah Raad, Eliza Hasen, Raja’a A Al-Qudah, Dinesh Kumar Chellappan, Tamara Athamneh, Mohammad AA Al-Najjar, Akram Ashames, How Effective are Nanotechnology-Based Therapeutics to Treat Autoimmune Diseases, International Journal of Nanomedicine, Jan 2026, doi: https://doi.org/10.2147/IJN.S562959
Autoimmune diseases are chronic, debilitating conditions caused by the immune system mistakenly attacking healthy tissues. Conventional treatments mainly involve broad immunosuppression, which is associated with significant side effects, limited specificity, and suboptimal long-term outcomes. For instance, continuing to take corticosteroids can result in a number of serious dose-linked toxicities, such as osteoporosis, hypertension, and a markedly increased susceptibility to infection, whereas methotrexate, even at therapeutic doses, can still cause liver damage and bone marrow suppression. This review aims to explore recent advances in nanotechnology-based therapies for autoimmune diseases, focusing on their mechanisms, therapeutic applications, and potential for clinical translation. A comprehensive review of peer-reviewed literature was conducted to examine various nanotechnology platforms, including drug-loaded nanoparticles, antigen-specific nanomedicines, RNA interference (siRNA), CRISPR-enabled systems, and stimuli-responsive nanocarriers. For instance, methotrexate-loaded polymeric nanoparticles dramatically decreased arthritis severity in preclinical rheumatoid arthritis rodents, whereas PLGA nanoparticles containing gluten protein induced immunological tolerance in a clinical study for celiac disease. Nanomedicine offers several advantages over traditional therapies, including targeted drug delivery, enhanced bioavailability, reduced systemic toxicity, and the potential to induce immune tolerance. Notable innovations include biodegradable polymeric nanoparticles, liposomes, micelles, exosome-mimetic nanoparticles, and magnetic nanomaterials. Emerging technologies, such as CRISPR-Cas9 and RNAi, delivered via nanoparticles, are advancing immune modulation in autoimmune models. Despite promising outcomes, several barriers remain, including concerns about toxicity, scale-up manufacturing issues, and regulatory challenges. Nanotechnology is redefining autoimmune disease therapy by shifting from non-specific immunosuppression to precision-targeted approaches. Future progress lies in integrating nanomedicine with personalized medicine to tailor treatments based on individual immune profiles. Continued interdisciplinary collaboration and regulatory alignment are essential to translating these innovations into clinical practice.
About the journal
Tahneem Yaseen, Muhammad Umair Afzal, Mustafa A Alhamaidah, Amer Hayat Khan, Musarrat Rrauf Burki, Mudassar Iqbal Arain, Akram A Ashames, Pooled frequency of ceftriaxone-induced urolithiasis in pediatric patients: a systematic review and meta-analysis, Pediatric Nephrology, Jun 2026, doi: https://doi.org/10.1007/s00467-026-07358-8
Background Ceftriaxone-associated biliary pseudolithiasis is well reported, but the true risk of urolithiasis remains less clearly defined. Prior reviews frequently combine biliary and urinary tract calcifications or rely mainly on descriptive findings, limiting accurate incidence estimates. Objective This systematic review and meta-analysis aimed to provide the first pooled frequency estimate specifically for ceftriaxone-induced urolithiasis in children. Data sources A systematic search of PubMed, Google Scholar, Web of Science, and Scopus was conducted up to November 2025. Study eligibility criteria Studies reporting the cases of urolithiasis in pediatric patients receiving ceftriaxone were included. Study appraisal and data synthesis Data extraction and synthesis were performed by two independent reviewers and analyzed by Stata 19.5. Pooled proportions were calculated using a random-effects model with REML estimation to determine overall frequency, between-study variance (τ2), and 95% prediction intervals (PI). Results Eight studies met the inclusion criteria. The pooled frequency of ceftriaxone-induced urolithiasis was 7% (95% CI: 2–12%). Heterogeneity was substantial (I2 = 89.8%; τ2 = 0.0034), and the 95% PI ranged from 2.7 to 15.8%. Subgroup analyses showed that retrospective studies from Asian regions reported markedly higher rates (up to 34%), whereas prospective Western studies consistently demonstrated lower frequencies. Sensitivity analysis excluding the main outlier reduced the pooled estimate to 4% (p = 0.004). Publication bias was detected (Egger’s test, p = 0.006), indicating underreporting of studies with low event rates. Conclusions and implications of key findings This meta-analysis suggests that ceftriaxone-associated urinary tract lithiasis occurs in approximately 7% of pediatric patients, with substantial variability driven by study design and diagnostic approach. Well-powered, prospective studies with standardized imaging protocols are required to define the true incidence and modifiable risk factors.
About the journal
Ghaseb N Makhadmeh, Abdulsalam Abuelsamen, Mahmoud Al-Gharram, Akram Ashames, Samer H Zyoud, M-Ali H Al-Akhras, Khaled Aljarrah, Mohamed Abdelfattah, Omar Mouhtady, Tariq AlZoubi, Optimized Talaporfin-Encapsulated by Silica Nanoparticles for In-Vitro Photodynamic Therapy Against MCF-7 Cancer Cells, Chemical Physics Impact, Mar 2026, doi: https://doi.org/10.1016/j.chphi.2026.101048
Photodynamic therapy (PDT) has emerged as a potent light-activated modality for selective and minimally invasive cancer treatment, utilizing the activation of photosensitizing agents by light to induce localized cytotoxic effects. Despite its therapeutic potential, the clinical efficiency of PDT is often limited by the inadequate delivery of photosensitizers to cancer sites due to rapid clearance by the reticuloendothelial system. In this study, silica nanoparticles (SiNPs) were investigated as nanocarriers by encapsulation for the photosensitizer Talaporfin to enhance targeted delivery and reduce systemic toxicity. The SiNPs were synthesized and characterized using Transmission Electron Microscopy (TEM) to confirm their morphology and size distribution. The photodynamic efficacy of both naked and Talaporfin-encapsulated SiNPs was evaluated in vitro against MCF-7 breast cancer cells. A series of cytotoxicity assays were conducted at varying concentrations and red laser irradiation intensities (∼110 mW/cm²) to determine optimal treatment parameters. The Talaporfin-encapsulated by SiNPs exhibited markedly superior therapeutic performance, achieving approximately 50% higher cellular uptake efficiency and a 45% reduction in required irradiation time compared to naked Talaporfin. These results demonstrate that SiNP-mediated delivery significantly enhances PDT outcomes through improved targeting and controlled drug release. Overall, this work highlights the potential of silica-based nanoplatforms as efficient vehicles for photosensitizer delivery in cancer phototherapy, paving the way for more effective and selective treatment modalities.
About the journal
Noor Kamal Raisan, Moawia M Al-Tabakha, Akram Ashames, Evaluating community pharmacists’ dispensing and counseling practices of semaglutide for weight loss in the United Arab Emirates: A simulated patient study, Pharmacy Practice, Mar 2026, doi: https://doi.org/10.18549/PharmPract.2026.1.3476
Background The rising global prevalence of obesity has led to increased demand for medications such as Semaglutide (Ozempic®), which is approved for the treatment of type 2 diabetes. However, its off-label use for weight loss has raised international concerns regarding misuse, patient safety, and pharmacist accountability. Objectives This study aimed to assess whether community pharmacists in the UAE dispense Ozempic® without a valid prescription and to evaluate the quality and comprehensiveness of pharmacists’ screening and counseling regarding Ozempic®. Methods A cross-sectional study was conducted using the simulated patient (SP) methodology. A trained SP visited 153 randomly selected community pharmacies across Dubai and the Northern Emirates and requested Ozempic® without a prescription for weight loss. Data was collected using a structured checklist covering prescription requirements, screening practices, and counseling quality. Results Of the 153 pharmacies visited, only a minority (26.8%) requested a prescription for Ozempic® before dispensing the medication. Chain pharmacies (35.4%) and female pharmacists (38.6%) were significantly more likely to request a prescription (p = 0.011 and p = 0.004). Additionally, when comparing the total percentage of pharmacists willing to dispense the medication without a prescription to a hypothetical benchmark of 50%, the difference was statistically significant (p
About the journal
Khaled Aljarrah, M-Ali H Al-Akhras, Ghaseb Makhadmeh, Abdulsalam Abuelsamen, Mahmoud Al Gharram, Samer Zyoud, Akram Ashames, Tariq AlZoubi, Enhancing Photodynamic Therapy via Encapsulated Temoporfin by Silica Nanoparticles: A Red Blood Cell–Based Efficacy and Modeling Study, Photodiagnosis and Photodynamic Therapy, Feb 2026, doi: https://doi.org/10.1016/j.pdpdt.2026.105391
Photodynamic Therapy (PDT) is an effective treatment in select cancers.. Unfortunately, in clinical practice, PDT may be hindered by poor delivery and stability of the photosensitizers, which are essential for conducting PDT, as well as by significant side effects and aggregation. The aim of this study was to incorporate the second-generation chlorin-based photosensitizer, Temoporfin, into silica nanoparticles (SiNPs) to improve the safety and efficacy of PDT. Due to their ability to control the delivery of oxygen to the tumor microenvironment, red blood cells (RBCs) were chosen as biological targets. Selective photodynamic damage to red blood cells may influence oxygen transport dynamics in the local microenvironment, suggesting a potential mechanism that could be relevant to tumor-associated hypoxia in future therapeutic models. Temoporfin was microemulsified, encapsulated within silica nanoparticles, and characterized for size, shape, and stability. Multiple photodynamic experiments were conducted with varying concentrations and exposure times to compare free Temoporfin and the encapsulated formulation. The formulation encapsulated in silica nanoparticles demonstrated photodynamic effects at much lower doses and shorter exposure times compared to the free formulation, largely due to improved light absorption, enhanced reactive oxygen species generation, and reduced aggregation of the photosensitizer within the silica polymer. The observations of this study provide a detailed reference for the design and fabrication of efficient photodynamic therapy systems, and the silica nanoparticles are encouraged to be used for sustained photosensitizer delivery. In addition, mathematical models were developed to relate the concentration of the drug to the time required to induce 50 % RBC death (t₅₀) for both free and encapsulated Temoporfin. These models provide an initial estimate for refining PDT treatment parameters and can help limit extensive experimental optimization. Overall, the study underscores the efficacy of silica nanoparticles as drug carrier systems for photosensitizers and supports their use in developing more refined, efficient, and biocompatible PDT approaches. This approach can be particularly useful for future cancer treatment models and can be extended to other areas of biomedicine.
About the journal
Akram Ashames, Saleha Anwar, Md Nayab Sulaimani, Pinky, Mohd Shahnawaz Khan, Moyad Shahwan, Suhel Parvez, Md Imtaiyaz Hassan, Khuzin Dinislam, Anas Shamsi, Targeting cancer metabolism through p-cresol mediated Inhibition of pyruvate dehydrogenase kinase 3 in lung cancer, Scientific Reports, Nov 2025, doi: https://doi.org/10.1038/s41598-025-25246-3
This study provides insight into therapy for lung cancer, establishing p-Cresol (p-C) as an inhibitor of Pyruvate Dehydrogenase Kinase 3 (PDK3). PDK3 is critical in cancer metabolism by regulating the pyruvate dehydrogenase complex, shifting cellular energy production towards glycolysis, and promoting tumor growth and survival under hypoxic conditions. In this study, we have used computational and experimental approaches. Molecular docking reveals that p-C occupies PDK3’s binding pocket and forms interactions with key residues, especially Asp 287. Molecular dynamic simulation (MD) studies showed that p-C induced minimum alterations in PDK3, suggesting the structural stability of the PDK3-p-C complex. A fluorescence-based binding study demonstrated the binding of p-C to PDK3 with a binding constant of 3.8 × 108 M−1, indicating excellent binding affinity. Cell-based enzyme assay revealed significant inhibition of PDK3 by p-C, establishing it as a PDK3 inhibitor. Moreover, cellular assays also demonstrated significant inhibition of PDK3 activity and tumor progression. This study provides a promising therapeutic avenue for improving lung cancer treatment outcomes by targeting PDK3.
About the journal
Anas Shamsi, Nojood Altwaijry, Moyad Shahwan, Akram Ashames, Dharmendra Kumar Yadav, Mohammad Furkan, Rizwan Hasan Khan, Identification of potential inhibitors of Ubiquitin carboxyl-terminal hydrolase 21 from repurposed drugs: Implications in anticancer therapeutics, Chemical Physics Impact, Jun 2025, doi: https://doi.org/10.1016/j.chphi.2024.100792
Ubiquitin carboxyl-terminal hydrolase 21 (USP21) is involved in the regulation of multiple cellular processes and participates in tumorigenesis. Due to its importance in the onset and progression of cancer, USP21 has become an appealing target in anticancer drug discovery. Therefore, this study aimed to screen a collection of repurposed drugs from the DrugBank 6.0 database for possible USP21 inhibitors. At the beginning of the selection process, the library was filtered by the binding efficiency to USP21, which identified a few drug molecules with appreciable binding affinity towards the USP21 binding pocket. These shortlisted molecules were then scrutinized based on their drug profiles and biological activities, with reference to their anticancer potential. Among them, Nilotinib and Radotinib were identified as the top candidates, with higher Pa values for anticancer activity. The interaction analysis and molecular dynamics (MD) simulation study further confirmed that both Nilotinib and Radotinib bind to the important and common residues of the USP21 binding site, which may inhibit the aberrant activity of USP21 in pathological conditions. The 500 ns MD simulations showed that both drugs are capable of binding to USP21 without any significant structural changes, which justifies their likelihood of being used as repurposed agents for cancer treatment. The RMSD, Rg, and hydrogen bond analyses showed minimal fluctuations, indicating high conformational stability. Additionally, free energy landscape (FEL) analysis supported the stability of the complexes. These results suggest that Nilotinib and Radotinib could serve as promising repurposed agents for USP21 inhibition in cancer treatment after required validation. In conclusion, the combination of docking and MD simulations highlights their potential therapeutic relevance, laying the groundwork for further development of USP21 inhibitors as anticancer drugs.
About the journal
Zehra Edis, Samir Haj Bloukh, Akram Ashames, Moawia M Al-Tabakha, Moyad JSA Shahwan, Hamed Abu Sara, Sai HS Boddu, Sohaib N Khan, Ibrahim Haj Bloukh, Maram Eladdasy, Somayeh Sadeghi, Haneen Abdulmalek Alkubaisi, Iman Haj Bloukh, Nageeb AGM Hassan, Syzygium aromaticum extract mediated, sustainable Silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities, Frontiers in Chemistry, Jan 2025, doi: https://doi.org/10.3389/fchem.2024.1513150
Microorganisms are becoming resistant to drugs and antimicrobials, making it a significantly critical global issue. Nosocomial infections are resulting in alarmingly increasing rates of morbidity and mortality. Plant derived compounds hold numerous antimicrobial properties, making them a very capable source to counteract resistant microbial strains. Syzygium aromaticum (Clove) extract has been proven by studies to contain active ingredients that demonstrate antibacterial, antifungal, antioxidant, and insecticidal properties. It has also been used historically for its pain relief especially for tooth ache. Clove extract derived nanoparticle synthesis is a promising method of combining therapeutics with metals at nanoscale. Such nanostructured systems in combination with the heterocyclic antibiotic clarithromycin could potentiate the action of plant extracts, decrease drug side effects and improve antimicrobial activity. In this study, clove extract (C) was successfully used to synthesize silver nanoparticles (AgNP) to create AgNPC and AgNPCA (A = clarithromycin). The two compounds underwent different analytical methods consisting of SEM, EDS, DLS, UV-vis, FTIR and XRD. These nanoparticles were used against a variety of 10 pathogens and exhibited very good to intermediate antibacterial properties. AgNPC resulted in better antibacterial properties and smaller nanoparticle size. This study demonstrates the potential of clove extract mediated AgNP synthesis in combination with and without the antibiotic clarithromycin.
About the journal
Samer H Zyoud, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S Yahia, Ahed H Zyoud, Heba Y Zahran, Naser Qamhieh, Ghaseb N Makhadmeh, Tariq AlZoubi, Superior photocatalytic degradation of pharmaceuticals and antimicrobial Features of iron-doped zinc oxide sub-microparticles synthesized via laser-assisted chemical bath technique, Results in Engineering, Dec 2024, doi: https://doi.org/10.1016/j.rineng.2024.102875
Addressing the dual challenges of antimicrobial resistance and pharmaceutical contamination in wastewater is crucial for global health and environmental preservation. Predictions estimate up to 10 million annual deaths by 2050 due to antimicrobial resistance, underscoring the urgent need for innovative solutions. This study explores the potential of zinc oxide Sub-Microparticles (ZnO SMPs) doped with iron (Fe) to enhance the photocatalytic degradation of pharmaceutical compounds in water and improve antimicrobial efficacy. A green laser-assisted chemical bath synthesis method created ZnO SMPs with varying Fe dopant concentrations (1 %, 1.5 %, and 3 %). The synthesized Sub-Microparticles underwent rigorous structural analysis using X-ray diffractometry, SEM, EDX, FTIR, and UV–visible spectrophotometry techniques. Their photocatalytic performance was evaluated in the degradation of paracetamol under blue laser light, and their antimicrobial properties were assessed following CLSI guidelines. Structural analyses confirmed the hexagonal wurtzite structure of ZnO SMPs, with noticeable changes due to Fe doping, including a transition from sub-microrods to sub-microsheets and a redshift in the optical band gap. Photocatalytic tests revealed a significant enhancement in paracetamol degradation efficiency, increasing from 53.41 % with pure ZnO to 98.99 % with 3 % Fe-doped ZnO in 50 min. Antimicrobial assays demonstrated an increased inhibitory effect against pathogens, with Fe-doped ZnO outperforming control discs. This study substantiates the potential of Fe-doped ZnO SMPs in wastewater treatment and antimicrobial applications, showcasing significant improvements in photocatalytic degradation of pharmaceutical compounds and antimicrobial efficacy. The findings underscore the importance of continuing research in this domain for environmental and public health benefits.
About the journal
Samer H Zyoud, Samer O Alalalmeh, Omar E Hegazi, Jamil H Alami, Che Azurahanim Che Abdullah, IS Yahia, Nageeb Hassan, Akram Ashames, HY Zahran, Samir Haj Bloukh, Moyad Shahwan, Ahed H Zyoud, Ammar Abdulrahman Jairoun, Naser Qamhieh, Exploration of laser-assisted chemical bath for enhancing synthesis of undoped and nickel-doped zinc oxide and its potential applications in water purification and mitigating antimicrobial resistance, Optik, 315, Sep 2024, doi: https://doi.org/10.1016/j.ijleo.2024.172046
This study aims to explore the antimicrobial and photocatalytic efficiencies of pure and Ni-doped ZnO nanostructures produced via Laser-assisted Chemical Bath Synthesis (LACBS) to develop sustainable solutions for water treatment and pathogen control amid the global water crisis exacerbated by climate change and environmental pollution. Utilizing zinc acetate dihydrate and hexamethylenetetramine, the nanostructures were synthesized with Ni doping levels of 0.0 %, 1.5 %, 3.0 %, and 4.5 %, targeting their promising photocatalytic and antimicrobial properties to combat contaminants from pharmaceuticals, agriculture, and industries. Morphological analyses using Scanning Electron Microscopy showed a transition from hexagonal particles to nanoflowers, enhancing photocatalytic activity due to increased surface-to-volume ratio. X-ray Diffraction confirmed the hexagonal wurtzite structure, with variations in peak intensities indicating improved crystallinity with Ni doping. Energy Dispersive X-ray analysis verified the purity and successful incorporation of Ni. Photocatalytic assessments indicated up to 99.24 % degradation of Methylene Orange dye under blue laser irradiation within 60 minutes, correlating with Ni content. Antimicrobial tests demonstrated effective inhibition of pathogens such as Escherichia coli, Staphylococcus aureus, and additional strains like Candida albicans and Klebsiella pneumonia, with increasing zones of inhibition corresponding to higher Ni levels, extending up to 37 mm. The results underscore the dual functionality of ZnO nanostructures for applications in sustainable water treatment and antimicrobial controls, highlighting the need for future studies to examine the impacts of further increased doping concentrations on the material properties and efficacy.
About the journal
Samer H. Zyoud, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S. Yahia, Ahed H. Zyoud, Heba Y. Zahran, Naser Qamhieh, Ghaseb N. Makhadmeh, Tariq AlZoubi, Superior photocatalytic degradation of pharmaceuticals and antimicrobial Features of iron-doped zinc oxide sub-microparticles synthesized via laser-assisted chemical bath technique, Results in Engineering, 24, Sep 2024, doi: 10.1016/j.rineng.2024.102875
Addressing the dual challenges of antimicrobial resistance and pharmaceutical contamination in wastewater is crucial for global health and environmental preservation. Predictions estimate up to 10 million annual deaths by 2050 due to antimicrobial resistance, underscoring the urgent need for innovative solutions. This study explores the potential of zinc oxide Sub-Microparticles (ZnO SMPs) doped with iron (Fe) to enhance the photocatalytic degradation of pharmaceutical compounds in water and improve antimicrobial efficacy. A green laser-assisted chemical bath synthesis method created ZnO SMPs with varying Fe dopant concentrations (1 %, 1.5 %, and 3 %). The synthesized Sub-Microparticles underwent rigorous structural analysis using X-ray diffractometry, SEM, EDX, FTIR, and UV–visible spectrophotometry techniques. Their photocatalytic performance was evaluated in the degradation of paracetamol under blue laser light, and their antimicrobial properties were assessed following CLSI guidelines. Structural analyses confirmed the hexagonal wurtzite structure of ZnO SMPs, with noticeable changes due to Fe doping, including a transition from sub-microrods to sub-microsheets and a redshift in the optical band gap. Photocatalytic tests revealed a significant enhancement in paracetamol degradation efficiency, increasing from 53.41 % with pure ZnO to 98.99 % with 3 % Fe-doped ZnO in 50 min. Antimicrobial assays demonstrated an increased inhibitory effect against pathogens, with Fe-doped ZnO outperforming control discs. This study substantiates the potential of Fe-doped ZnO SMPs in wastewater treatment and antimicrobial applications, showcasing significant improvements in photocatalytic degradation of pharmaceutical compounds and antimicrobial efficacy. The findings underscore the importance of continuing research in this domain for environmental and public health benefits.
About the journal
Samer H Zyoud, Akram Ashames, Ahed H Zyoud, Anupama R Prasad, Che Azurahanim Che Abdullah, Shaher H Zyoud, Ibrahim S Yahia, Ghaseb N Makhadmeh, Awais Khalid, Naser Qamhieh, Heba Y Zahran, Sani Muhammad, Mohamed Sh Abdel-wahab, Advanced photodegradation and antimicrobial performance: A comparative study of Al/Ag-Co-doped ZnO synthesis via laser assist chemical bath, Materials Science and Engineering: B, 309, pp.117649 - , Nov 2024, doi: 10.1016/j.mseb.2024.117649
This study utilizes a novel laser-assisted chemical bath synthesis (LACBS) approach to dope zinc oxide (ZnO) nanostructures with aluminum (Al) and silver (Ag), examining enhancements in photocatalytic and antimicrobial capabilities. The configurations tested include undoped ZnO, singly-doped ZnO(0.05) and ZnO(0.05), and co-doped ZnO:[Ag(0.025), Al(0.025)]. X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses reveal shifts in lattice orientations and novel morphologies such as crumpled nano-flakes and interlocked flower-like formations. UV–visible spectroscopy results show a reduction in optical band gaps from 3.39 eV in undoped ZnO to 2.89 eV in co-doped samples. Photocatalytic activity testing under UV light reveals that undoped ZnO reaches a 68 % degradation efficiency of methylene blue over 10 min, while co-doped ZnO exhibits a superior 78.93 % efficiency under blue laser illumination. Antimicrobial assays indicate that co-doped ZnO inhibits Escherichia coli and Klebsiella pneumonia growth with zones of inhibition up to 40 mm, significantly larger than those observed with singly-doped or undoped samples. The integration of Al and Ag significantly enhances the crystalline structure, reduces the optical band gap by up to 0.50 eV, and increases both photocatalytic and antimicrobial effectiveness, marking substantial progress in the functional applications of ZnO nanostructures.
About the journal
Anas Shamsi, Moyad Shahwan, Saleha Anwar, Akram Ashames, Mohd Shahnawaz Khan & Dharmendra Kumar Yadav , Understanding the interactions between repurposed drugs sertindole and temoporfin with receptor for advanced glycation endproducts: Therapeutic implications in cancer and metabolic diseases, Journal of Molecular Modeling, 30, pp.170 - , May 2024, doi: https://doi.org/10.1007/s00894-024-05967-4
Context In the pursuit of novel therapeutic possibilities, repurposing existing drugs has gained prominence as an efficient strategy. The findings from our study highlight the potential of repurposed drugs as promising candidates against receptor for advanced glycation endproducts (RAGE) that offer therapeutic implications in cancer, neurodegenerative conditions and metabolic syndromes. Through careful analyses of binding affinities and interaction patterns, we identified a few promising candidates, ultimately focusing on sertindole and temoporfin. These candidates exhibited exceptional binding affinities, efficacy, and specificity within the RAGE binding pocket. Notably, they displayed a pronounced propensity to interact with the active site of RAGE. Our investigation further revealed that sertindole and temoporfin possess desirable pharmacological properties that highlighted them as attractive candidates for targeted drug development. Overall, our integrated computational approach provides a comprehensive understanding of the interactions between repurposed drugs, sertindole and temoporfin and RAGE that pave the way for future experimental validation and drug development endeavors. Methods We present an integrated approach utilizing molecular docking and extensive molecular dynamics (MD) simulations to evaluate the potential of FDA-approved drugs, sourced from DrugBank, against RAGE. To gain deeper insights into the binding mechanisms of the elucidated candidate repurposed drugs, sertindole and temoporfin with RAGE, we conducted extensive all-atom MD simulations, spanning 500 nanoseconds (ns). These simulations elucidated the conformational dynamics and stability of the RAGE-sertindole and RAGE-temoporfin complexes.
About the journal
Ihsan Ali Mahar, Aneela Tahira, Mehnaz Parveen, Ahmed Ali Hulio, Zahoor Ahmed Ibupoto, Muhammad Ali Bhatti, Elmuez Dawi, Ayman Nafady, Riyadh H Alshammari, Brigitte Vigolo, Kezhen Qi, Elfatih Mustafa, Lama Saleem, Akram Ashames, Zafar Hussain Ibupoto, Glucose sensing via green synthesis of NiO–SiO2 composites with citrus lemon peel extract, Journal of Materials Science: Materials in Electronics, 35, pp.490 - , Mar 2024, doi: 10.1007/s10854-024-12156-9
In this study, NiO–SiO2-based composites were synthesized through low-temperature aqueous chemical growth utilizing a facile, low-cost, and environmentally friendly approach. The composite systems were prepared using a combination of silica gel and citrus lemon peel extract. Due to the remarkable green chemicals in orange peel extract, porous nanostructures have been developed with thin sheet-like properties. The composite materials were examined in terms of their crystalline structure, morphology, optical band gap, and surface chemical composition. An advanced non-enzymatic glucose sensor developed from NiO–SiO2 composites exhibits rich surface oxygen vacancies and abundant catalytic sites. Based on sample 2, cyclic voltammetry revealed a linear glucose concentration range between 0.1 and 20 mM, chronoamperometry exhibited glucose concentration ranges between 0.1 and 14 mM, and linear sweep voltammetry revealed glucose concentration ranges from 0.1 to 10 mM. In enzymatic glucose sensors, the minimum level of detection was estimated to be 0.08 mM. A number of sensor characterization parameters were examined, including selectivity, stability, reproducibility, and real-time applications. In addition, electrochemical impedance spectroscopy (EIS) has shown that the NiO–SiO2 composite performs well in non-enzymatic glucose sensing due to its low charge transfer resistance and high electrochemical active surface area (ECSA). NiO–SiO2 composites could have significant biomedical, energy conversion, and storage applications based on the results obtained.
About the journal
Akram Ashames, Munaza Ijaz, Manal Buabeid, Haya Yasin, Sidra Yaseen, Richie R. Bhandare, Ghulam Murtaza , In Vivo Wound Healing Potential and Molecular Pathways of Amniotic Fluid and Moringa Olifera-Loaded Nanoclay Films, Molecules, 29, pp.729 - , Feb 2024, doi: 10.3390/molecules29030729
Cutaneous wounds pose a significant health burden, affecting millions of individuals annually and placing strain on healthcare systems and society. Nanofilm biomaterials have emerged as promising interfaces between materials and biology, offering potential for various biomedical applications. To explore this potential, our study aimed to assess the wound healing efficacy of amniotic fluid and Moringa olifera-loaded nanoclay films by using in vivo models. Additionally, we investigated the antioxidant and antibacterial properties of these films. Using a burn wound healing model on rabbits, both infected and non-infected wounds were treated with the nanoclay films for a duration of twenty-one days on by following protocols approved by the Animal Ethics Committee. We evaluated wound contraction, proinflammatory mediators, and growth factors levels by analyzing blood samples. Histopathological changes and skin integrity were assessed through H&E staining. Statistical analysis was performed using SPSS software (version 2; Chicago, IL, USA) with significance set at p < 0.05. Our findings demonstrated a significant dose-dependent increase in wound contraction in the 2%, 4%, and 8% AMF-Me.mo treatment groups throughout the study (p < 0.001). Moreover, macroscopic analysis revealed comparable effects (p > 0.05) between the 8% AMF-Me.mo treatment group and the standard treatment. Histopathological examination confirmed the preservation of skin architecture and complete epidermal closure in both infected and non-infected wounds treated with AMF-Me.mo-loaded nanofilms. RT-PCR analysis revealed elevated concentrations of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF), along with decreased levels of tumor necrosis factor-alpha (TNF-α) in AMF-Me.mo-loaded nanofilm treatment groups. Additionally, the antimicrobial activity of AMF-Me.mo-loaded nanofilms contributed to the decontamination of the wound site, positioning them as potential candidates for effective wound healing. However, further extensive clinical trials-based studies are necessary to confirm these findings.
About the journal
Adeel Liaquat Bhatti, Aneela Tahira, Imran Ali Halepoto, Shusheel Kumar, Zaheer Ahmed Ujjan, Ayman Nafady, Nemah Abu Shama, Elmuez Dawi, Akram Ashames, Lama Saleem, Matteo Tonezzer, Antonia Infantes-Molin & Zafar Hussain Ibupoto , Green-Mediated Synthesis of Co3O4 Nanostructures for Efficient Oxygen Evolution Reaction and Supercapacitor Applications, Journal of Electronic Materials, 53, pp.1012 - 1025, Feb 2024, doi: https://doi.org/10.1007/s11664-023-10846-4
A simple, scalable, and environmentally friendly process was demonstrated for the synthesis of Co3O4 nanostructures using lemon juice and hydrothermal chemistry. The reducing, capping, and stabilizing agents in lemon juice result in improved performance in oxygen evolution reactions and supercapacitors due to their positive effects on morphology, crystal size, and surface defects. Several techniques were used to characterize Co3O4 nanostructures grown with different quantities of lemon juice, including field emission scanning electron microscopy, energy-dispersive spectroscopy, and x-ray diffraction. The results show that lemon juice alters the size and homogeneity of Co3O4 nanostructures as well as surface defects like oxygen vacancies and interstitial Co. A sample prepared with 4 mL of lemon juice (sample 1) performed best, demonstrating an overpotential of 260 mV at 10 mA cm−2 and good stability at 20 mA cm−2 for 40 h. With the prepared nanomaterial, supercapacitors were developed with a specific capacitance of 398 F g−1 at 0.8 A g−1, a specific capacity retention percentage of 97%, a high energy density of 9.5 Wh kg−1, and excellent stability during 880 galvanic charge and discharge cycles. Co3O4 nanostructures have experienced dramatic improvements in electrochemical performance as a result of morphological changes and oxygen vacancy concentrations on their surfaces. By reducing, capping, and stabilizing lemon juice, a new generation of electroactive electrodes have been developed for storage and conversion of energy.
About the journal
Samer H. Zyoud, Bayan M. Al Radi, Bashayer M. Al Maamari, Mohamed Nasor, H. Y. Zahran, I. S. Yahia, Taimoor Ahmad, Sohaib N. Khan, Ahed H. Zyoud, Moyad Shahwan, Nageeb Hassan, Akram Ashames, Malek G. Daher, Ghaseb N. Makhadmeh, Naser Qamhieh, Ammar Abdulrahman Jairoun & Mohamed Sh. Abdel-wahab , Efficient Al-doped ZnO nanostructured synthesis by laser-assisted chemical bath: structural, optical, and photocatalytic activity using blue laser irradiation, Indian Journal of Physics, 98, pp.549 - 560, Feb 2024, doi: https://doi.org/10.1007/s12648-023-02828-3
This study used laser-assisted chemical bath synthesis (LACBS) as a simple, catalyst-free hydrothermal approach to synthesize pure and Al-doped ZnO nanostructures. Under the influence of a blue laser, the photocatalytic degradation of methylene blue has been studied (444.5 nm of wavelength and 8000 lx of light intensity). For the first time, LACBS produced numerous doping concentrations (2, 4, and 6%) using a continuous blue laser (power is 7 W and wavelength is 444.5 nm). X-ray diffraction (XRD), scanning electron microscopy (FE-SEM), and UV–vis spectrophotometry were used to verify the structural and optical properties of the prepared nanostructures. It has been demonstrated that ZnO:Al (6%) nanosheets have a significant role in the rapid photodegradation caused by blue laser irradiation. The efficiency for methylene blue degradation varies from 85.9, 86.3, and 99.4 to 99.7% for the pure and ZnO:Al (2, 4, and 6%), respectively. This improved photocatalytic activity is attributed to the increased catalytic activity and surface area of Al-doped ZnO. Using UV–visible spectroscopy, the photocatalytic efficiency was determined from the absorption spectra. The photocatalytic activity is increased due to a combination of the Al-plasmonic effect and ZnO surface imperfections that enable the separation of photogenerated electron–hole pairs and shift the absorption edge of the hybrid nanostructure toward the visible spectrum region. Effective visible light absorption and improved dye degradation efficiency are caused by band-edge tuning in ZnO:Al nanostructured.
About the journal
Samer H. Zyoud, Omar E. Hegazi, Samer O. Alalalmeh, Che Azurahanim Che Abdullah, Akram Ashames, Nageeb Hassan, Ibrahim S. Yahia, Ahed H. Zyoud, Malek G. Daher, Moyad Shahwan, Samir Haj Bloukh, Heba Y. Zahran, Naser Qamhieh, Mohamed Nasor, Ammar Jairoun , Enhancing Antimicrobial and Photocatalyst Properties of Mg-Doped ZnO Nanotubes via a Novel Laser-Assisted Chemical Bath Synthesis, Journal of Saudi Chemical Society, Oct 2023, doi: 10.1016/j.jscs.2023.101752
Laser-Assisted Chemical Bath Synthesis (LACBS) was used to fabricate pure and magnesium-doped zinc oxide nanoparticles. Analysis of these nanoparticles' structural, morphological, optical, and antimicrobial characteristics was conducted. This analysis spanned across varying concentrations of magnesium-doped zinc oxide from 1% to 3%. XRD confirmed the nanoparticles' crystalline nature, revealing the hexagonal wurtzite phase. SEM analysis showcased their nanometric domain existence and hexagonal crystalline morphology, transforming from nanorods to nanotubes. Optical analysis showed band gap energy decrease from 3.27 to 2.85 eV correlating with the magnesium doping concentration increase. Optical absorption displayed a distinctive redshift for the nanoparticles as magnesium concentration increased from 1% to 3%. Photocatalytic assessments highlighted the superior degradation ability of 3% Mg-doped nanoparticles, showing a 98.04% degradation rate against methylene orange dye under blue light exposure. Antimicrobial activity tests against various pathogens showed that Mg ions' incorporation significantly enhanced antimicrobial performance, demonstrating the effectiveness of the LACBS method.
About the journal
Samer H Zyoud, Omar E Hegazi, Samer O Alalalmeh, IS Yahia, HY Zahran, Samir Haj Bloukh, Hamed Abu Sara, Ahed H Zyoud, Moyad Shahwan, Akram Ashames, Nageeb Hassan, Malek G Daher, Ghaseb N Makhadmeh, Ammar Abdulrahman Jairoun, Elbadawy A Kamoun, Enhanced photocatalytic and antimicrobial properties of undoped and aluminum-doped zinc oxide nanosheets synthesized via novel laser-assisted chemical bath technique, Applied Physics A, 129, Oct 2023, doi: https://doi.org/10.1007/s00339-023-07033-x
The urgency of antibiotic resistance has been recognized, necessitating prompt, and focused efforts from the scientific community. Innovative alternatives, such as nanoparticles and photocatalytic agents, have been investigated to confront drug-resistant microbes. As an antimicrobial and photocatalytic agent, zinc oxide (ZnO) has demonstrated considerable promise. This study utilized a cutting-edge method called laser-assisted chemical bath synthesis (LACBS) to create undoped and Al-doped ZnO nanostructures without a catalyst. X-ray diffraction (XRD), scanning electron microscopy (SEM), UV–Vis spectrophotometry, and Fourier-transform infrared spectra (FTIR) were used to verify the structural and optical properties of the prepared nanostructures. The influence of doping concentration was evaluated by producing samples with doping concentrations of 1%, 2%, and 3%, and they were assessed employing diverse analytical techniques. It was found that ZnO exhibited the most pronounced antimicrobial activity: Al(3%) nanosheets, which can be attributed to their extensive surface area and the photocatalytic activity induced by LACBS. These materials displayed exceptional performance in the degradation of methylene orange. The integration of aluminum was observed to expedite interfacial charge transfer processes and diminish recombination, thereby enhancing the photocatalytic activity of the ZnO nanosheets. These findings emphasize the potential of aluminum-doped zinc oxide nanosheets as wide-ranging microbicides and disinfectants, underlining their significance in addressing drug-resistant microbes. Adopting such sophisticated materials could pave the way for creating potent antibacterial agents capable of tackling the escalating issue of antibiotic resistance. Subsequent research ought to concentrate on assessing the impact of augmented doping levels on the investigated variables.
About the journal
Karim Kakaei, Mohsen Padervand, Yuksel Akinay, Elmuez Dawi, Akram Ashames, Lama Saleem, Chuanyi Wang, A critical mini-review on challenge of gaseous O 3 toward removal of viral bioaerosols from indoor air based on collision theory, Environmental Science and Pollution Research, Jun 2023, doi: http://dx.doi.org/10.1007/s11356-023-28402-2
COVID-19, a pandemic of acute respiratory syndrome diseases, led to significant social, economic, psychological, and public health impacts. It was not only uncontrolled but caused serious problems at the outbreak time. Physical contact and airborne transmission are the main routes of transmission for bioaerosols such as SARS-CoV-2. According to the Centers for Disease Control (CDC) and World Health Organization (WHO), surfaces should be disinfected with chlorine dioxide, sodium hypochlorite, and quaternary compounds, while wearing masks, maintaining social distance, and ventilating are strongly recommended to protect against viral aerosols. Ozone generators have gained much attention for purifying public places and workplaces’ atmosphere, from airborne bioaerosols, with specific reference to the COVID-19 pandemic outbreak. Despite the scientific concern, some bioaerosols, such as SARS-CoV-2, are not inactivated by ozone under its standard tolerable concentrations for human. Previous reports did not consider the ratio of surface area to volume, relative humidity, temperature, product of time in concentration, and half-life time simultaneously. Furthermore, the use of high doses of exposure can seriously threaten human health and safety since ozone is shown to have a high half-life at ambient conditions (several hours at 55% of relative humidity). Herein, making use of the reports on ozone physicochemical behavior in multiphase environments alongside the collision theory principles, we demonstrate that ozone is ineffective against a typical bioaerosol, SARS-CoV-2, at nonharmful concentrations for human beings in air. Ozone half-life and its durability in indoor air, as major concerns, are also highlighted in particular.
About the journal
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Atiya Akhtar, PF543-like compound, a promising sphingosine kinase 1 inhibitor: Structure-based virtual screening and molecular dynamic simulation approaches, International Journal of Biological Macromolecules, 245, Jun 2023, doi: 10.1016/j.ijbiomac.2023.125466
Sphingosine kinase 1 (SphK1) has been widely recognized as a significant contributor to various types of cancer, including breast, lung, prostate, and hematological cancers. This research aimed to find a potential SphK1 inhibitor through a step-by-step virtual screening of PF543 (a known SphK1 inhibitor)-like compounds obtained from the PubChem library with the Tanimoto threshold of 80 %. The virtual screening process included several steps, namely physicochemical and ADMET evaluation, PAINS filtering, and molecular docking, followed by molecular dynamics (MD) simulation and principal component analysis (PCA). The results showed that compound CID:58293960 ((3R)-1,1-dioxo-2-[[3-[(4-phenylphenoxy)methyl]phenyl]methyl]-1,2-thiazolidine-3-carboxylic acid) demonstrated high potential as SphK1 inhibitor. All-atom MD simulations were performed for 100 ns to evaluate the stability and structural changes of the docked complexes in an aqueous environment. The analysis of the time evolution data of structural deviations, compactness, PCA, and free energy landscape (FEL) indicated that the binding of CID:58293960 with SphK1 is relatively stable throughout the simulation. The results of this study provide a platform for the discovery and development of new anticancer therapeutics targeting SphK1.
About the journal
Sakineh Fotouhi, Maher Assaad, Mohamed Nasor, Ahmed Imran, Akram Ashames and Mohammad Fotouhi, Multivariable Signal Processing for Characterization of Failure Modes in Thin-Ply Hybrid Laminates Using Acoustic Emission Sensors, Sensors, 23, pp.5244 - , May 2023, doi: 10.3390/s23115244
The aim of this study was to find the correlation between failure modes and acoustic emission (AE) events in a comprehensive range of thin-ply pseudo-ductile hybrid composite laminates when loaded under uniaxial tension. The investigated hybrid laminates were Unidirectional (UD), Quasi-Isotropic (QI) and open-hole QI configurations composed of S-glass and several thin carbon prepregs. The laminates exhibited stress-strain responses that follow the elastic-yielding-hardening pattern commonly observed in ductile metals. The laminates experienced different sizes of gradual failure modes of carbon ply fragmentation and dispersed delamination. To analyze the correlation between these failure modes and AE signals, a multivariable clustering method was employed using Gaussian mixture model. The clustering results and visual observations were used to determine two AE clusters, corresponding to fragmentation and delamination modes, with high amplitude, energy, and duration signals linked to fragmentation. In contrast to the common belief, there was no correlation between the high frequency signals and the carbon fibre fragmentation. The multivariable AE analysis was able to identify fibre fracture and delamination and their sequence. However, the quantitative assessment of these failure modes was influenced by the nature of failure that depends on various factors, such as stacking sequence, material properties, energy release rate, and geometry.
About the journal
E. A. Dawi, E. Mustafa, M. Padervand, A. Ashames, S. Hajiahmadi, L. Saleem, M. Baghernejad, O. Nur & M. Willander , Ag/AgCl Decorated Ionic Liquid@Tantalum Pentoxide Nanostructures: Fabrication, Photocatalytic Activity, and Cytotoxicity Effects Against Human Brain Tumor Cells, Journal of Inorganic and Organometallic Polymers and Materials, May 2023, doi: https://doi.org/10.1007/s10904-023-02693-x
Environmental contaminants have become a major concern for human beings due to their adverse effects on drinking water quality. Heterogeneous photocatalysis has been extensively investigated as a potential strategy to minimize the consequences of as-related processes. Using a room-temperature ionic liquid-mediated co-precipitation method, Ag@AgCl nanoparticles were loaded onto tantalum pentoxide to make a plasmonic photocatalyst to remove Congo Red dye. The physicochemical properties of the photocatalysts were characterized by X-ray diffraction powder (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), Diffuse Reflectance Spectroscopy (DRS), Fourier-transform infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM), photoluminescence (PL), and nitrogen adsorption–desorption isotherms. The results indicate that 96% of the dye was degraded within 20 min with a rate constant of 0.14 min−1. The key radicals involved in the photocatalysis, recognized as O2·– species, were identified by electron spin resonance (ESR) in the presence of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), as the spin trapping agent. Our findings and quenching experiments elucidates the mechanism of the charge carrier migration. The cytotoxicity activity of the nanostructures was also examined against human brain glioblastoma tumor cells for the first time. A precise analysis of the cell death pathway was conducted using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), mitochondrial membrane potential (MMP), reactive oxygen species (ROS), and caspase activity assays in combination with fluorescence microscopy images. The prepared nanomaterials were found to be promising candidates for treating the organic pollutants and biomedical waste effluents from academic and industrial activities.
About the journal
Samer H. Zyoud, Samer O. Alalalmeh, Omar E. Hegazi, Ibrahim S. Yahia, Heba Y. Zahran, Hamed Abu Sara, Samir Haj Bloukh, Moyad Shahwan, Ahed H. Zyoud, Nageeb Hassan, Akram Ashames, Malek G. Daher, Ghaseb N. Makhadmeh, Ammar Jairoun, Naser Qamhieh, and Mohamed Sh. Abdel-wahab, Novel Laser-Assisted Chemical Bath Synthesis of Pure and Silver-Doped Zinc Oxide Nanoparticles with Improved Antimicrobial and Photocatalytic Properties, Catalysts, 13, pp.900 - 923, May 2023, doi: 10.3390/catal13050900
Antimicrobial resistance poses a significant threat to global health, amplified by factors such as water scarcity and suboptimal hygienic practices. Addressing AMR effectively necessitates a comprehensive strategy encompassing enhanced access to potable water, developing innovative antibiotics, and exploring alternative treatment modalities, such as harnessing solar photocatalysis with zinc oxide nanoparticles for water purification and antimicrobial applications. The Laser-Assisted Chemical Bath Synthesis (LACBS) technique facilitates the fabrication of pure ZnO nanostructures, providing a potentially efficacious solution for mitigating pathogen proliferation and managing wastewater. The photocatalytic degradation of MB and MO dyes was investigated using blue laser light at 445 nm, and degradation rates were determined accordingly. Ag-doped ZnO nanostructures were characterized through X-ray diffraction, field emission scanning electron microscopy, energy dispersive X-ray spectroscopy, and Fourier-transform infrared spectroscopy. The antimicrobial efficacy of LACBS-synthesized ZnO nanoparticles was assessed against C. albicans, S. aureus, B. subtilis, E. coli, and K. pneumoniae using the disc diffusion method, revealing 40 mm, 37 mm, 21 mm, 27 mm, and 45 mm inhibition zones at the highest concentration of doped-Ag (4.5%), respectively. These inhibition zones were measured in accordance with the guidelines established by the Clinical and Laboratory Standards Institute. X-ray diffraction patterns for ZnO, ZnOAg(1.5%), ZnO:Ag(3%), and ZnO:Ag(4.5%) samples revealed variations in intensity and crystallinity. Scanning electron microscopy exposed morphological disparities among the nanostructures, while energy-dispersive X-ray spectroscopy verified their elemental compositions. UV-Vis absorption analyses inspected the optical band gaps, and Fourier-transform infrared spectra identified the stretching mode of metal-oxygen bonds. Under blue laser irradiation, Ag-doped ZnO exhibited enhanced photocatalytic activity during the photocatalytic degradation. These nanoparticles, synthesized via the cost-effective and straightforward LACBS method, benefit from silver doping that augments their electron-trapping properties and photocatalytic activity, thereby enabling efficient dye degradation. Consequently, Ag-doped ZnO nanoparticles hold promise as a potent solution for counteracting drug-resistant microorganisms and as an effective disinfectant.
About the journal
Sumaiya Kifayat, Vidyasrilekha Yele, Akram Ashames, Dilep Kumar Sigalapalli, Richie R. Bhandare, Afzal B. Shaik, Venkatarathnam Nasipireddyg and Bharat Kumar Reddy Sanapalli , Filamentous temperature sensitive mutant Z: a putative target to combat antibacterial resistance, RSC Advances, 13, pp.11368 - 11384, Apr 2023, doi: https://doi.org/10.1039/D3RA00013C
In the pre-antibiotic era, common bacterial infections accounted for high mortality and morbidity. Moreover, the discovery of penicillin in 1928 marked the beginning of an antibiotic revolution, and this antibiotic era witnessed the discovery of many novel antibiotics, a golden era. However, the misuse or overuse of these antibiotics, natural resistance that existed even before the antibiotics were discovered, genetic variations in bacteria, natural selection, and acquisition of resistance from one species to another consistently increased the resistance to the existing antibacterial targets. Antibacterial resistance (ABR) is now becoming an ever-increasing concern jeopardizing global health. Henceforth, there is an urgent unmet need to discover novel compounds to combat ABR, which act through untapped pathways/mechanisms. Filamentous Temperature Sensitive mutant Z (FtsZ) is one such unique target, a tubulin homolog involved in developing a cytoskeletal framework for the cytokinetic ring. Additionally, its pivotal role in bacterial cell division and the lack of homologous structural protein in mammals makes it a potential antibacterial target for developing novel molecules. Approximately 2176 X-crystal structures of FtsZ were available, which initiated the research efforts to develop novel antibacterial agents. The literature has reported several natural, semisynthetic, peptides, and synthetic molecules as FtsZ inhibitors. This review provides valuable insights into the basic crystal structure of FtsZ, its inhibitors, and their inhibitory activities. This review also describes the available in vitro detection and quantification methods of FtsZ-drug complexes and the various approaches for determining drugs targeting FtsZ polymerization.
About the journal
Samer H. Zyoud, Ibrahim S. Yahia, Moyad Shahwan, Ahed H. Zyoud, Heba Y. Zahran, Mohamed Sh. Abdel-wahab, Malek G. Daher, Mohamed Nasor, Ghaseb N. Makhadmeh, Nageeb Hassan, Akram Ashames, Naser Qamhieh , Fast and Excellent Enhanced Photocatalytic Degradation of Methylene Blue Using Silver-Doped Zinc Oxide Submicron Structures under Blue Laser Irradiation, Crystals, 13, pp.229 - , Jan 2023, doi: https://doi.org/10.3390/cryst13020229
In this study, laser-assisted chemical bath synthesis (LACBS) was used to prepare pure and Ag-doped ZnO submicron structures using a simplified hydrothermal approach that did not require a catalyst. The photocatalytic degradation of Methylene Blue was investigated under blue laser irradiation (λ = 444.5 nm and I = 8000 lx). The doping concentration varied (2%, 4%, 6%, 8%, tando 10%) and was prepared by LACBS using a continuous blue laser (P = 7 W, λ = 444.5 nm) for the first time. XRD, FE-SEM, EDX, and UV-Vis investigated the characteristics of the samples produced by the LACBS. ZnO: Ag(10%) submicron flowers are essential in rapid photodegradation under blue laser irradiation. The high surface area and catalytic activity of the prepared Ag-decorated ZnO are attributed to this improved photocatalytic activity. Using UV-visible spectroscopy, the photocatalytic efficiency was determined from the absorption spectra. The separation of photo-generated electron-hole pairs was facilitated, and the absorption edge of the hybrid submicron structures shifted into the visible spectrum region due to a combination of the Ag plasmonic effect and surface imperfections in ZnO. Effective visible light absorption was achieved via band-edge tuning, which increased the ZnO:Ag submicron structures’ ability to degrade dyes.
About the journal
Jada Naga Lakshmi, Ankem Narendra Babu, S. S. Mani Kiran, Lakshmi Prasanthi Nori, Nageeb Hassan, Akram Ashames, Richie R. Bhandare, Afzal B. Shaik, Herbs as a Source for the Treatment of Polycystic Ovarian Syndrome: A Systematic Review, BioTech, 12, pp.4 - , Jan 2023, doi: 10.3390/biotech12010004
Background: Polycystic ovarian syndrome (PCOS) is a neuroendocrine metabolic disorder characterized by an irregular menstrual cycle. Treatment for PCOS using synthetic drugs is effective. However, PCOS patients are attracted towards natural remedies due to the effective therapeutic outcomes with natural drugs and the limitations of allopathic medicines. In view of the significance of herbal remedies, herein, we discuss the role of different herbs in PCOS. Methods: By referring to the Scopus, PubMed, Google Scholar, Crossref and Hinari databases, a thorough literature search was conducted and data mining was performed pertaining to the effectiveness of herbal remedies against PCOS. Results: In this review, we discuss the significance of herbal remedies in the treatment of PCOS, and the chemical composition, mechanism of action and therapeutic application of selected herbal drugs against PCOS. Conclusions: The present review will be an excellent resource for researchers working on understanding the role of herbal medicine in PCOS.
About the journal
Mustafa Ameen AlHamaidah, Noora Noureldin, Adham Yehia, Ibrahim Alani, Abdelaziz Al-Qussain, Osama Abdou, Akram Ashames, Zelal Kharaba , Efficacy and Short-Term Safety of COVID-19 Vaccines: A Cross-Sectional Study on Vaccinated People in the UAE, Vaccines, 10, pp.2157 - , Dec 2022, doi: https://doi.org/10.3390/vaccines10122157
Background: The emergence of COVID-19 has been a major challenge to public health and the world economy. During a wave of COVID-19, the usage of widespread vaccination procedures and broader coverage to the whole of humanity will be made possible if the general population has access. An intended effect of vaccination is to provide “herd immunity,” which protects those who have not been vaccinated along with those who have been. However, some concerns regarding the safety and efficacy of COVID-19 vaccines were raised. Aim: This study aims to provide evidence on the short-term safety and efficacy of four types of vaccines that are officially approved by the Ministry of Health in the United Arab Emirates (UAE). These include Sinopharm, Sputnik V, Pfizer, and AstraZeneca. Method: This study utilized a cross-sectional descriptive design. Data on the efficacy and short-term protection of COVID-19 vaccines on vaccinated citizens and residents (n = 764) of the UAE were collected between February and April 2021. Participants were conveniently approached using a Google Forms survey, where they responded to a semi-structured questionnaire pertaining to socio-demographic questions and in-depth questions related to COVID-19, including whether they suffer from any comorbidities, the most commonly encountered post-vaccination side effects, and the severity of their symptoms, using a 5-point Likert scale. Results were analyzed using SPSS version 24, calculations of p-values and descriptive statistics were used for data differentiation. Results: The majority of the participants (n = 612 or 94.4%) stated that they did not become reinfected after receiving two doses of COVID-19 vaccine. In addition, the incidence of being hospitalized after vaccination was negligible. In terms of adverse effects, the most common individually reported side effects, regardless of the vaccination type, included “pain at the site of injection”, followed by “general fatigue”, then “lethargy”. Moreover, most of these side effects occurred after the second dose of the vaccine, irrespective of the type of vaccine. Females were found to be more susceptible to the adversities of COVID-19 vaccination. The occurrence of side effects was not found to be related to the nationality/ethnicity of the vaccine recipient. Furthermore, none of the vaccines affected sleep pattern, since a significant number of respondents reported a regular sleep pattern after being vaccinated. The majority respondents who received two doses of vaccination (n = 585 or 76.6%) reported that they did not become infected post vaccination, regardless the type of vaccine received, whereas only (n = 11 or 1.9%) were reinfected with COVID-19 after 2–4 weeks. Conclusion: The findings of this study suggest that vaccines can offer short-term protection against COVID-19 reinfection. Moreover, both the first- and second-vaccination side effects were described as very mild to moderate, which indicates tolerability. These data may strengthen the public confidence in receiving vaccinations.
About the journal
Bharat Kumar Reddy Sanapalli, Akram Ashames, Dilep Kumar Sigalapalli, Afzal B Shaik, Richie R Bhandare, Vidyasrilekha Yele, Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review, Antibiotics, 11, pp.1680 - , Nov 2022, doi: 10.3390/antibiotics11121680
Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines (IZPs) are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Only one IZP, i.e., rifaximin, is available on the market as an antibiotic. In this review, the authors highlight strategies for preparing other IZPs. A particular focus is on the antibacterial profile and structure–activity relationship (SAR) of various synthesized IZP derivatives. This research provides a foundation for the tuning of available compounds to create novel, potent antibacterial agents with fewer side effects.
About the journal
Akram Ashames, Fahad Pervaiz, Moawia Al-Tabakha, Kanza Khalid, Nageeb Hassan, Hina Shoukat, Manal Buabeid, Ghulam Murtaza, Synthesis of Cross-linked Carboxymethyl Cellulose and Poly (2-Acrylamido-2-methylpropane Sulfonic Acid) Hydrogel for Sustained Drug Release Optimized by Box-Behnken Design, Journal of Saudi Chemical Society, Sep 2022, doi: 10.1016/j.jscs.2022.101541
This research aims to fabricate and characterize chemically crosslinked CMC/PVP-co-poly (AMPS) based hydrogel for the sustained release of model drug metoprolol tartrate through the free radical polymerization technique. Box-Behnken Design was used to optimize CMC/PVP-co-poly (AMPS) hydrogel by varying the content of reactants such as; polymers (CMC and PVP), monomer (AMPS), and crosslinker (EGDMA). Carboxymethyl cellulose (CMC) was crosslinked chemically with AMPS with a constant ratio of PVP by the ethylene glycol dimethacrylate as the crosslinker in the presence of sodium hydrogen sulfite (SHS)/ammonium peroxodisulfate (APS) as initiators. After developing CMC-based hydrogels using different polymers, monomer, and crosslinker concentrations, this study encompassed dynamic swelling, sol-gel fraction, drug release and chemical characterizations such as FTIR, XRD, TGA, DSC, and SEM. In vitro drug release and swelling were performed at 1.2 and 6.8 pH to determine the sustained release pattern and pH-responsive behavior. These parameters depended on the crosslinker, polymer, and monomer ratios used in the formulation development. XRD, SEM, and FTIR showed the successful grafting of constituents resulting in the formation of a stable hydrogel. DSC and TGA confirmed the thermodynamic stability of the hydrogel. Hydrogel swelling was increased with an increase in the ratio of monomer; however, an increase in the ratio of polymer and crosslinker decreased the hydrogel swelling. In vitro gel fraction and drug release also depended on polymer, monomer, and crosslinker ratios. The fabricated CMC/PVP-co-poly (AMPS) hydrogels constituted a potential system for sustained drug delivery.
About the journal
Akram Ashames, Kaleem Ullah, Moawia Al-Tabakha, Shujaat Ali Khan, Nageeb Hassan, Abdul Mannan, Muhammad Ikram, Manal Buabeid, Ghulam Murtaza , Development, characterization and In-vitro evaluation of guar gum based new polymeric matrices for controlled delivery using metformin HCl as model drug, Plos One, 17, pp.e0271623 - , Jul 2022, doi: 10.1371/journal.pone.0271623
Currently, hydrogels are considered as ideal biomaterials due to their unique structure and characteristics that facilitates considerable hydrophilicity, swelling, drug loading and release. In this study, we report pH-responsive GG-MAA-AMPS hydrogel delivery system prepared via free radical polymerization technique. Hydrogels were loaded with Metformin HCl as a model drug. Hydrogels were characterized through Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). FTIR confirmed the successful crosslinking of reactants, hydrogel network formation and drug loading. TGA and DSC proved the higher thermal stability of reactants after crosslinking and drug loading. XRD analysis showed decrease in crystallinity of drug after loading into the hydrogels. SEM revealed smooth and glassy appearance of both loaded and unloaded hydrogels. Gel content was increased with increase in concentration of reactants. Drug entrapment was decreased by increasing concentration of GG and AMPS while MAA acted inversely. Hydrogels displayed pH-dependent swelling and drug release behavior being high at pH 6.8 and 7.4 while low at acidic pH (1.2). Oral tolerability in rabbits showed that hydrogels were safe without causing any hematological or histopathological changes in healthy rabbits. Based on the obtained results, GG-MAA-AMPS can be considered as potential carrier for metformin HCl as well as other hydrophilic drugs.
About the journal
Urooj Afreen, Khairi Mustafa Fahelelbom, Syed Nisar Hussain Shah, Akram Ashames, Uzma Almas, Shujaat Ali Khan, Muhammad Arfat Yameen, Naveed Nisar, Muhammad Hassham Hassan Bin Asad, Ghulam Murtaza , Formulation and evaluation of niosomes-based chlorpheniramine gel for the treatment of mild to moderate skin allergy, Journal of Experimental Nanoscience, 17, pp.467 - 495, Jul 2022, doi: 10.1080/17458080.2022.2094915
Purpose of present study was to develop eight formulations of chlorpheniramine (CPM) niosomes according to 23 factorial design, characterise on the basis of various evaluation tests, i.e. in vitro drug release, SEM, FTIR, TGA and release kinetics, optimise the eight formulation on the basis in vitro drug release data, formulate gel of optimised dispersion, and to perform in vivo and histopathological study using gel of optimised dispersion on rabbits. Here, N3 having low level of cholesterol and span-80 but high level of span-60(0.1:0.2:0.05) was selected as optimised dispersion of niosomes that showed highest drug release i.e. 88.25% at pH 6 over 24 h of study and followed Korsmeyers-Peppas release kinetics with Fickian diffusion mechanism. After application of statistic by Analysis of variance (ANOVA) with 3D surface plots construction, gel of optimised dispersion of CPM niosomes was formulated, and evaluated by tests for i.e. viscosity, Spreadability, Extrudibility, drug content, drug entrapment, stability, SEM, FTIR, TGA, in vitro drug release, in vivo drug release following first order kinetics and histopathological study. Niosomal gel of CPM ensured successful development using suitable combination of non-ionic surfactants, and effective loading of drug for targeted delivery of drug.
About the journal
Badriyah Shadid Alotaibi, Akram Ashames, Manal Buabeid, Momina Masood, Sadullah Mir, Ghulam Murtaza, A new approach for the management of Escherichia coli and Klebsiella pneumonia by using cefixime-based bionanocomposite films, Journal of Experimental Nanoscience, 1, pp.389 - 419, Jun 2022, doi: 10.1080/17458080.2022.2080197
Purpose: The aim of this study was to assess the antibacterial potential and ex vivo skin permeation kinetics of cefixime from bionanocomposite films. Methods: The films were prepared by solvent casting method by using chitosan and starch. The fabricated films were tested for their antibacterial potential against three bacteria i.e. Escherichia coli, Klebsiella pneumonia, and Acetobacter aceti. In vitro permeation studies of cefixime from the films across rat skin was conducted using Franz diffusion cell. Results: The highest antibacterial effect was exhibited by F5 formulation (non-irradiated film) against Escherichia coli and Klebsiella pneumonia; however, antibacterial activity of the films was significantly (p
About the journal
Zeeshan Patel, Sankalp Gharat, Anita D. Chando, Munira Momin, Moawia M. Al-Tabakha, Akram Ashames, Sai HS. Boddu, Recent advancements in Electrospun Nanofibers for Wound Healing: Polymers, Clinical and Regulatory Perspective, Critical Reviews in Therapeutic Drug Carrier Systems, 39, Jan 2022
Wound management is an unmet therapeutic challenge and a global healthcare burden. Current treatment strategies provide limited efficiency in wound management, thus undergoing constant evolution in the treatment approaches. As wound healing is a complex physiological process involving precise synchronization of various phases like haemostasis, inflammation and remodelling, which necessitates innovative treatment strategies. Nanotechnology platforms like polymeric nanofibers (NFs) offer a promising solution for wound management. NFs contain a porous mesh-like structure that mimics the natural extracellular matrix and promote the cell adhesion and proliferation in the wound bed, thus displaying a great potential as a wound healing scaffold. Electrospinning is a simple, versatile and scalable technique for producing highly porous and tuneable NFs with a high surface area. Electrospun NFs are presenting extensive application in wound management, especially for burns and diabetic foot ulcers. This review briefly discusses the wound physiology and conventional treatment strategies. It also provides an overview of the electrospinning process and its principle, highlighting the application of electrospun polymeric NFs in wound management. The authors have made an attempt to emphasizes on the clinical challenges and future perspectives along with regulatory aspects of NFs as a wound dressing.
About the journal
Khairi Mustafa Fahelelbom, Abdullah Saleh, Moawia M. A. Al-Tabakha and Akram A. Ashames, Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: A brief review, Reviews in Analytical Chemistry, 41, pp.21 - 33, Jan 2022, doi: https://doi.org/10.1515/revac-2022-0030
Qualitative Fourier transform infrared (FTIR) spectroscopy has long been established and implemented in a wide variety of fields including pharmaceutical, biomedical, and clinical fields. While the quantitative applications are yet to reach their full potential, this technique is flourishing. It is tempting to shed light on modern engaging and the applicability of analytical quantitative FTIR spectroscopy in the aforementioned fields. More importantly, the credibility, validity, and generality of the application will be thoroughly demonstrated by reviewing the latest published work in the scientific literature. Utilizing FTIR spectroscopy in a quantitative approach in pharmaceutical, biomedical, and interdisciplinary fields has many undeniable advantages over traditional procedures. An insightful account will be undertaken in this regard. The technique will be introduced as an appealing alternative to common methods such as high performance liquid chromatography. It is anticipated that the review will offer researchers an update of the current status and prospect on the subject among the pharmacy and biomedical sciences both in academic and industrial fields.
About the journal
Wlla Wail Al-Halbouni, Moawia M Altabakha, Akram A Ashames, Adi I Arida, Muaed J Alomar, Osteosarcoma Occurrence in Preclinical and Clinical Experiments with Teriparatide: A Qualitative Review, Thai Journal of Pharmaceutical Sciences (TJPS), 46, pp.120 - 126, Mar 2022
Teriparatide (TPTD) is one of the medications commonly prescribed for the treatment of osteoporosis since its approval in November 2002 by the US Food and Drug Administration (FDA). While some preclinical toxicological studies have linked the drug to a dose-dependent increase in the occurrence of osteosarcoma, clinical trials showed the benefits outweighing the risk for TPTD-induced human osteosarcoma. The objective of this qualitative review was to qualitatively assess the literature for the association of osteosarcoma and the usage of TPTD in animal and human subjects. Studies were selected from all available records in the electronic databases covering the period from January 1, 2002, to September 30, 2020. While using rats as the study specimen showed some risks to osteosarcoma dependent on dose and duration of administration, clinical trials proved TPTD to be a safe treatment in humans. It is worthwhile investigating longer treatment periods than the two years labeled period for TPTD for safety purposes.
About the journal
Badriyah Shadid Alotaibi, Fahad Pervaiz, Manal Buabeid, Akram Ashames, Khairi Mustafa Fahelelbom, Sana Siddique, Hina Shoukat, Sadia Rehman, Sobia Noreen, Ghulam Murtaza. Nanostructured Lipid Carriers Based Suppository for Enhanced Rectal Absorption of Ondansetron: In vitro and In vivo Evaluations. Arabian Journal of Chemistry, 14(12) 103426 (2021)
Ameena Asheq, Akram Ashames, Moawia Al-Tabakha, Nageeb Hassan, Ammar Jairoun. Medication adherence in type 2 diabetes mellitus patients during Covid-19 pandemic: a cross-sectional study from the United Arab Emirates. F1000Research, 10, 435 (2021)
Sobia Noreen, Fahad Pervaiz, Akram Ashames, Manal Buabeid, Khairi Fahelelbom, Hina Shoukat, Irsah Maqbool, Ghulam Murtaza. Optimization of Novel Naproxen-Loaded Chitosan/Carrageenan Nanocarrier-Based Gel for Topical Delivery: Ex Vivo, Histopathological, and In Vivo Evaluation. Pharmaceuticals, 14(6), 557 (2021)
Moawia M. Al-Tabakha, Shujaat Ali Khan, Akram Ashames, Hamid Ullah, Kaleem Ullah, Ghulam Murtaza, Nageeb Hassan. Synthesis, Characterization and Safety Evaluation of Sericin-Based Hydrogels for Controlled Delivery of Acyclovir. Pharmaceuticals, 14(3), 234 (2021)
Subish Palaian, Manal Buabeid, Akram Ashames. Patient Safety Culture in Handling Prescriptions and Interprofessional Collaboration Practices Amongst Community Pharmacists: An Investigative Simulated Patient Study from the United Arab Emirates. Risk Management and Healthcare Policy, 13, 3201—3209 (2020)
Ammar Abdulrahman Jairoun, Sabaa Saleh Al-Hemyari, Moyad Shahwan, Sa’ed H Zyoud, Akram Ashames. Hidden Formaldehyde Content in Cosmeceuticals Containing Preservatives that Release Formaldehyde and Their Compliance Behaviors: Bridging the Gap between Compliance and Local Regulation. Cosmetics, 7(4), 93 (2020)
Richie Bhandare, Vaishali Londhe, Akram Ashames, Nadeem Shaikh, Sham Zain Alabdin. Enhanced Solubility of Microwave-assisted Synthesized Acyclovir Co-crystals. Research Journal of Pharmacy and Technology, 13, 12, 5979-5986 (2020)
Sai HS Boddu, Diwakar B Tukaramrao, Moawia M Al-Tabakha, Akram Ashames, Rabin Neupane, R Jayachandra Babu, Jwala Renukuntla, Amit K Tiwari, Evaluation of Cytotoxicity and Taste-Masking Effect of Selected Flavors on Dental Lidocaine HCl Injection. Pharmaceuticals, 13, 11, 253 (2020)
Shujaat Ali Khan, Wajeeha Azam, Akram Ashames, Khairi Mustafa Fahelelbom, Kaleem Ullah, Abdul Mannan, Ghulam Murtaza. β-Cyclodextrin-based (IA-co-AMPS) Semi-IPNs as Smart Biomaterials for Oral Delivery of Hydrophilic Drugs: Synthesis, Characterization, In-Vitro and In-Vivo Evaluation. Journal of Drug Delivery Science and Technology, 60, (2020), 101970
Ashames et al, Pharmaceutical Quality Attributes of Various Brands of Metformin Hydrochloride Tablets from UAE Market Including Recently Recalled Products. Research Journal of Pharmacy and Technology;14(2) (2021), Accepted
Jianxian Chen, Akram Ashames, Manal Ali Buabeid, Khairi Mustafa Fahelelbom, Muhammad Ijaz, Ghulam Murtazad. Nanocomposites drug delivery systems for the healing of bone fractures. International Journal of Pharmaceutics; 585, 119477 (2020)
Ashames et al, Development and Ex-Vivo Skin Permeation Studies of Finasteride-PLGA and Minoxidil- Chitosan Nanoparticulate Systems. Journal of Bioactive and Compatible Polymers, 35 (2), 77-91 (2020)
A Shah, AA Ashames, MA Buabeid, G Murtaza. Synthesis, in vitro characterization and antibacterial efficacy of moxifloxacin-loaded chitosan-pullulan-silver-nanocomposite films. Journal of Drug Delivery Science and Technology, 55, 101366 (2020)
May Reda, Akram Ashames, Zehra Edis, Samir Bloukh, Richie Bhandare, Hamed Abu Sara. Green synthesis of potent antimicrobial silver nanoparticles using different plant extracts and their mixtures. Processes 7 (8), 510 (2019)
Akram Ashames. Bachelor of Pharmacy Programs in United Arab Emirates. Universal Journal of Educational Research 7 (8), 1650-1662 (2019)
Akram Ashames, Richie Bhandare, Sham Zain AlAbdin, Tasnim Alhalabi, Farah Jassem. Public perception toward e-commerce of medicines and comparative pharmaceutical quality assessment study of two different products of furosemide tablets from community and illicit online pharmacies. Journal of Pharmacy And Bioallied Sciences 11(3), 284 (2019)
Akram Ashames, Nageeb Hassan, Kristen Alamir, Kamar Modalaleh, Alin Naser, Aya Khawatmi. Correlation between Neck Circumference, Waist Circumference, Body Mass Index, and Overweight/Obesity among Ajman University Students, Research J. Pharm. and Tech. 12(5), 2443-2452 (2019)
Akram Ashames, Richie Bhandare, Sham Zain AlAbdin, Amna Aljashamy, Aya Atfeh, Abir Elwaer, Noura Fakhry. In vitro Comparative Quality Attributes of Selected Brands of Fexofenadine Hydrochloride Tablets Marketed in UAE and India. Book title: Chemistry for a Clean and Healthy Planet (Chapter 5), Springer, September 2019)
Zehra Edis, Samir Haj Bloukh, Akram Ashames, May Ibrahim. Copper-based nanoparticles, their chemistry and antibacterial properties: A Review. Book title: Chemistry for a Clean and Healthy Planet (Chapter 24), Springer, September 2019)
Akram Ashames, Sham Zain AlAbdin, Fatima ElZahra ElMahdi, Asma Samhi, Manar Farraj. Qualitative and quantitative characterization of hazardous triclosan traces in household personal care soaps marketed in UAE. Journal of Pharmaceutical Sciences and Research,11 (1), 89-92 (2019).
Akram Ashames, Moawia M. Al-Tabakha, Sham Zain AlAbdin, Zainab Ahmad. Tablet Splitting: Public Perception and Quality Attributes of Two Common Cardiovascular Drugs. Research Journal of Pharmacy and Technology, 11, (12), 5562-5568 (2018).
Heena D. Patel, Moayad Al Shahwan, Akram Ashames, Mohammed Waseemul Islam, Richie Bhandare. One pot microwave-assisted synthesis of 3-benzyl-5hydroxymethyl-1,3-oxazolidin-2-one. Journal of Pharmaceutical Sciences and Research, 10 (11), 2814-281 (2018).
Amal Ammar, Mohamed El-Attug, Amal Belaid, Sakina Sadaawi, Ruwida Kamour, Akram Ashames, Tariq Almog and Shukri Alsharif. Separation of complexed semi-synthetic flavonoids by using fused core column in short time. Journal of Chemical and Pharmaceutical Research 8 (3), 438-443 (2016).
S. Kim Williams Ratanathanawongs, J. Ray Runyon, Akram A. Ashames. Field-Flow Fractionation: Addressing the Nano Challenge. Anal. Chem., 83 (3), 634–642 (2011).
S. Kim Williams Ratanathanawongs, Marie-Anna Benincasa, Akram A. Ashames. Field-Flow Fractionation in Analysis of Polymers and Rubbers. Encyclopedia of Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester. DOI:10.1002/9780470027318.a2008.pub2 (2009).
Conference Presentation
- Akram Ashames. New approach in exosomes separation to uniform pure subpopulations. 6th International Conference of Pharmacy & Medicine, Sharjah, UAE, January 18-20, 2022
- Akram Ashames, Tom Anchordoquy, Michael Graner, S. Kim R. Williams. "Uniform Preparations of Tumor-Derived Exosomes Using a Two-Dimensional Field-Flow Fractionation Approach." 20th International Symposium on Field- and Flow-Based Separations (FFF2020), Vienna, Austria, February 22-27, 2020.
- Akram Ashames. "E-Commerce of Pharmaceuticals and Nutraceuticals in the UAE." 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, Abu Dhabi, UAE, September 22-26, 2019.
- 2019 World Federation for Medical Education World Conference (Seoul, Korea, April 7-10, 2019) Akram Ashames. Recent Developments in Undergraduate Pharmacy Education in United Arab Emirates Toward Clinical and Social Pharmacy
- World Nano 2019 (Dubai, April 15-19, 2019) May Reda Mohamed and Akram Ashames Comparative study of antimicrobial activity of various silver nanoparticles synthesized by various green methods
- 31st International Symposium on Chromatography (ISC 2016), Adel M. Abushoffa, Akram A. Ashames, Jamal S. Mezogi, Prospective study of substandard and counterfeit medicines in the North African region
- 249th American Chemical Society (ACS) Meeting 2015, Denver, CO (USA), C Bria, A Ashames, P Skelly, SK Williams, Semipreparative asymmetric flow field-flow fractionation for nanoparticle characterization
- FFF Conference 2014, Salt Lake City, UT (USA). Akram A. Ashames, Seamus McMullen, Tom Anchordoquy, Michael Graner, Kim Williams “Development of a two-dimensional field-flow fractionation method for tumor-derived exosomes”.
- Exosomes and Microvesicles Conference 2012, Orlando, FL (USA). Akram A. Ashames, Seamus McMullen, Kim Williams “Novel 2D separation of exosomes by Field-Flow Fractionation”.
- ExoExpo 2012, Colorado (USA), Akram A. Ashames, Seamus McMullen, Kim Williams “Novel 2D separation of exosomes”
- ExoExpo 2011, Colorado (USA), Akram A. Ashames, Seamus McMullen, Kim Williams “Asymmetrical flow field-flow fractionation of exosomes”.
Akram Ashames. New approach in exosomes separation to uniform pure subpopulations. 6th International Conference of Pharmacy & Medicine, Sharjah, UAE, January 18-20, 2022
Akram Ashames, Tom Anchordoquy, Michael Graner, S. Kim R. Williams. "Uniform Preparations of Tumor-Derived Exosomes Using a Two-Dimensional Field-Flow Fractionation Approach." 20th International Symposium on Field- and Flow-Based Separations (FFF2020), Vienna, Austria, February 22-27, 2020.
Akram Ashames. "E-Commerce of Pharmaceuticals and Nutraceuticals in the UAE." 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, Abu Dhabi, UAE, September 22-26, 2019.
2019 World Federation for Medical Education World Conference (Seoul, Korea, April 7-10, 2019) Akram Ashames. Recent Developments in Undergraduate Pharmacy Education in United Arab Emirates Toward Clinical and Social Pharmacy
World Nano 2019 (Dubai, April 15-19, 2019) May Reda Mohamed and Akram Ashames Comparative study of antimicrobial activity of various silver nanoparticles synthesized by various green methods
31st International Symposium on Chromatography (ISC 2016), Adel M. Abushoffa, Akram A. Ashames, Jamal S. Mezogi, Prospective study of substandard and counterfeit medicines in the North African region
249th American Chemical Society (ACS) Meeting 2015, Denver, CO (USA), C Bria, A Ashames, P Skelly, SK Williams, Semipreparative asymmetric flow field-flow fractionation for nanoparticle characterization
FFF Conference 2014, Salt Lake City, UT (USA). Akram A. Ashames, Seamus McMullen, Tom Anchordoquy, Michael Graner, Kim Williams “Development of a two-dimensional field-flow fractionation method for tumor-derived exosomes”.
Exosomes and Microvesicles Conference 2012, Orlando, FL (USA). Akram A. Ashames, Seamus McMullen, Kim Williams “Novel 2D separation of exosomes by Field-Flow Fractionation”.
ExoExpo 2012, Colorado (USA), Akram A. Ashames, Seamus McMullen, Kim Williams “Novel 2D separation of exosomes”
ExoExpo 2011, Colorado (USA), Akram A. Ashames, Seamus McMullen, Kim Williams “Asymmetrical flow field-flow fractionation of exosomes”.
Memberships, Awards and Honors
- Member of the Ajman University Council for Academic Affairs (CfAA), since 2022.
- Chair, Ajman University Council for Admission, Registration and Enrollment (CARE), since 2022.
- Member of the College Council, since 2016.
- American Society for Exosomes and Microvesicles (ASEMV), since 2012.
- PBD Honor Society Gold Medal for Outstanding Scholar Achievement, Colorado School of Mines, Golden, Colorado, USA, 2012.
- Materials Science Fellowship, Colorado School of Mines, 2010-2011, Golden, Colorado,USA, 2011.
- University Graduate Study Scholarship from the Libyan Government for Doctoral Degree, Libyan Government, 2000 and 2007.
- Certificate of Achievement for Outstanding Undergraduate Student in the Arab World Universities, Yarmouk University, Jordan, 1993.
- Editorial Board Member of the Journal of Pharmacy Practice and Pharmaceutical Sciences.
- Editorial Board Member of the Journal of Pharmaceutical Quality Assurance and Quality Control.
- Editorial Board Member of Trends in Pharmaceuticals and Nanotechnology.
- Editorial Board Member of the Journal of Pharma and Drug Regulatory Affairs.
- Conference Awards at the Dubai International Pharmaceuticals & Technological Conference & Exhibition (DUPHAT), 2017 and 2018.
- AU Research Day 2018 Awards for Supervising the Best Undergraduate and Graduate Student Projects.
- Member of the ACPE Steering Committee at the College of Pharmacy and Health Sciences, Ajman University.
- Chair of the Drug Design, Analysis, and Delivery Research Group, since January 2017.
- Arbitrator for the Rashid Bin Humaid Award for Culture and Science, since 2017.
- Head of Laboratories, College of Pharmacy and Health Sciences.
- Libyan Pharmacist Syndicate.
- Libyan Society for Pharmaceutical Sciences.
- The First Place and Best Pharmacy Student Innovative Poster Award was presented to students Batoul Baradie and Haneen Abufares, along with their supervisor Dr. Akram Ashames, for their work titled "Fat Burners: A Solution or a Scam?"
- The Sixth Best Pharmacy Student Oral Presentation Award was presented to students Alaa Ahmad, Huda Ahmad, Alanoud Alattari, and Ruba Alnajjar, along with their supervisors Dr. Akram Ashames and Sabrina Ait Gacem, for their work titled "Pharmaceutical Quality Control Evaluation of Metformin Hydrochloride Tablets, Including Recently Recalled Products from the UAE Market."
- DUPHAT 2020 Award: Eighth Best Outstanding Poster Presentation for Students Under the Supervision of Dr. Akram Ashames, Dr. Manal Buabeid, and Dr. Subish Palaian for their Investigational Study to Evaluate the Predictors for Self-Medication Among the Public.