Elshaimaa Abdelrazek Ahmed Arafa

Elshaimaa Abdelrazek Ahmed Arafa

Associate Professor
Ext: 6242

Dr. El-Shaimaa A. Arafa is an associate professor of Pharmacology and Toxicology that joined the College of Pharmacy and Health Sciences in Ajman University, Ajman Campus in August 2014. She received her Ph.D. from Cairo university in Egypt under a joint program with The Ohio State University in USA in May 2009. Her career is a merge between research and academia; she had a research fellowship at the Ohio state University between June 2009 and December 2010 and she worked as an assistant and associate professor in different universities in Egypt, Saudi Arabia and Finally United Arab Emirates.

Education
  • Foreign Pharmacy Graduate Equivalency Certificate, FPGEC, USA, 2009
  • Ph.D, Cairo University & The Ohio State University, Egypt and USA, 2009
  • M.Sc., Cairo University, Egypt, 2005
  • B.Sc., Cairo University, Egypt, 1998
Experience
  • Associate Professor Department of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Ajman University, UAE, 3 year.
  • Associate Professor Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt, 5 years. (on-leave)
  • Assistant Professor, Department of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Ajman University, UAE, 2 years and 1 month.
  • Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taif University, KSA, 1 year.
  • Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Nahda University, Egypt, 1 year. (Part-time)
  • Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Egypt, one semester. (Part-time)
  • Postdoctoral Research Associate , Department of Radiology, Division of Radiobiology, The Ohio State University, USA, 1 year and 6 months.
  • Assistant Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt, 5 years. (3 years on-leave).
  • Visiting Scholar, Department of Radiobiology, The Ohio State University, USA, under the scholar exchange program of the Egyptian Ministry of Higher Education to obtain the PhD, 2 years.
  • Lecturer, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Egypt, 2 years.
  • Instructor and teaching assistant, Pharmacology & Toxicology Department, Faulty of Pharmacy, Cairo University, Egypt, 5 years.
Teaching Area
  • Pharmacology and Therapeutics
  • Toxicology
  • Bioassay and Drug Screening
  • Drug Abuse
  • Experimental Pharmacology
  • Pharmacology and Natural Products
Research
  • Molecular mechanisms of natural anticancer drugs
  • Molecular pharmacology as a basis for drugs development
  • Oxidative stress implication in the pathophysiology of clinical disorders
Publications
  • Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways. Advances in Pharmacology and Pharmaceutical Sciences. 2021. PMID: 33748757
  • In Silico Prediction of the Mode of Action of Viola odorata in Diabetes. Biomed Research International. 2020. PMID: 33490239
  • Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats. Journal of Diabetes Research. 2020. PMID: 33178838
  • Cuscuta reflexa Roxb. Expedites the Healing Process in Contact Frostbite. Biomed Research International. 2020. PMID: 33083466
  • Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations. International Journal of Endocrinology. 2020. PMID: 32963524
  • Protective Effects of Cocos Nucifera Oil in Paraphenylene Diamine Toxicity. Curr Pharm Biotechnol. 2020. PMID: 32351177
  • Gliclazide attenuates acetic acid-induced colitis via the modulation of PPARγ, NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology. March 2020, 391; 114919
  • Metformin: A Review of its Therapeutic Efficacy and Adverse Effects. Obesity Medicine. March 2020, 17; 100186
  • Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy. Journal of Immunology Research 2020; 9624532
  • Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation.PLoS One. 2020 Jan 13;15(1):e0227637.
  • The wound healing and antibacterial potential of triple-component nanocomposite (chitosan-silver-sericin) films loaded with moxifloxacin. Int J Pharm. 2019 Apr 16.
  • Added sugar: Nutritional knowledge and consumption pattern of a principal driver of obesity and diabetes among undergraduates in UAE.Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2579-2584.
  • Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors.Exp Eye Res. 2019 Sep;186:107742.
  • Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment. FEBS J. 2019 Sep;286(18):3540-3557.
  • Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma. Sci Rep. 2018 Aug 27;8(1):12914.
  • Tackling Cancer Resistance by Immunotherapy: Updated Clinical Impact and Safety of PD-1/PD-L1 Inhibitors. Cancers (Basel). 2018 Jan 25;10(2).
  • Camel Milk Attenuates Rheumatoid Arthritis Via Inhibition of Mitogen Activated Protein Kinase Pathway. Cell Physiol Biochem. 2017;43(2):540-552.
  • Thymoquinone Mitigate Ischemia-Reperfusion-Induced Liver Injury in Rats: A Pivotal Role of Nitric Oxide Signaling Pathway. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):69-76.
  • Zinc Chloride Protects against Streptozotocin-Induced Diabetic Nephropathy in Rats. Pharmacol Pharm, 2016 Aug; 7 (8): 331-342.
  • Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations. Chem Biol Interact. 2016 Oct 25;258:205-13.
  • Tangeretin alleviates cisplatin-induced acute hepatic injury in rats: Targeting MAPKs and apoptosis. PloS One, 2016 Mar;11(3).
  • Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacological Reports, 2016 April (68): 2, 349–356
  • Quercetin Modulates iNOS, eNOS and NOSTRIN Expressions and Attenuates Oxidative Stress in Warm Hepatic Ischemia-reperfusion Injury in Rats. Beni-Suef University Journal of Basic and Applied Sciences, 2015 September (4): 3,246-255.
  • Diosmin Protects against Ethanol-Induced Gastric Injury in Rats: Novel Anti-Ulcer Actions. PLoS One. 2015 Mar 30;10(3).
  • Beneficial effects of hesperidin against cisplatin-induced nephrotoxicity and oxidative stress in rats. British Journal of Pharmacology and Toxicology, 2015.
  • Decorosides A and B. Cytotoxic flavonoid glycosides from the leaves of Rhododendron decorum. Natural Product Communications, 2014. 9(4):473-476.
  • Camel’s milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress. Food Chem Tox, 2014 Apr 28; 69C:294-302.
  • Candesartan Modulates the Antioxidant Effect of Silymarin Against CCl4-Induced Liver Injury in Rats. Free Radicals and Antioxidants, 2014; 4(1):32-38.
  • Design, Synthesis and Pharmacological Evaluation of Novel Pyrrolizine Derivatives as Potential Anticancer Agents. Bioorg Chem. 2014 Apr; 53:1-7.
  • OSU-CG5, a Novel Energy Restriction Mimetic Agent Targets The Colorectal Cancer Cells. Acta Pharmacol Sin. 2014 Mar; 35(3):394-400.
  • . Sensitization of Hepatocellular Carcinoma Cells to Apo2L/TRAIL by a Novel Akt/NF-κB Signaling Inhibitor. Basic Clin Pharmacol Toxicol. 2014 Jun; 114(6):464-71.
  • OSU-A9 inhibits angiogenesis in human umbilical vein endothelial cells via disrupting Akt-NF-κB and MAPK signaling pathways. Toxicology and Applied Pharmacology. 2013 Nov 1; 272(3):616-24.
  • Antitumor effects of energy restriction-mimetic agents: thiazolidinediones. Biological Chemistry 2013 Jul; 394(7):865-70.
  • Protective effect of vitamin E and atorvastatin against potassium dichromate-induced nephrotoxicity in rats. Beni-Suef University Journal of Basic and Applied Sciences. June 2013, 2 (2); 96–102.
  • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat Res. 2011 Jan 10; 706(1-2):28-35.
  • Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis. Int J Cancer. 2010 Aug 15; 127(4):977-88.
  • Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. Cancer Res. 2009 Dec 1; 69(23):8910-7.
  • The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. J Biol Chem. 2008 Nov 21; 283(47):32553-61.
  • Naringenin protects HaCaT human keratinocytes against UVB-induced apoptosis and enhances the removal of cyclobutane pyrimidine dimers from the genome. Photochem Photobiol. 2008 Mar-Apr;84(2):307-16.
Conference Presentation
  • Tangeretin Protects against Ethanol-Induced Injury in Gastric Mucosa of Rats via its Antioxidants and Anti-inflammatory Activity. The FASEB Journal 33 (1_supplement), 505.16-505.16. April 2019.
  • Role of Nicotine Mediated Neuroprotection in MPTP-induced Parkinson’s disease. The FASEB Journal 33 (1_supplement), lb84-lb84. April 2019.
  • Quercitrin protects rats against cisplatin-induced renal and hepatic injury without hindering its beneficial cytotoxic activity. Experimental Biology. Chicago, IL, USA. April, 2017
  • Awareness and Knowledge of Vitamin D Deficiency and its Possible Risk Factors Among University Students in United Arab Emirates. DUPHAT. Dubai, UAE. March 2017.
  • Nanotechnology: the answer for the unsolved science mystery? DUPHAT. Dubai, UAE. March 2017.
  • Treatment of chronic nightmares: can we do it? DUPHAT. Dubai, UAE. March 2017.
  • Use of internet for health related information: results from cross-sectional study. DUPHAT. Dubai, UAE. March 2017.
  • Spray on Skin: Can it be the answer in Burns Healing?. DUPHAT. Dubai, UAE. March 2017.
  • Over the counter drugs misuse in UAE: Findings from cross- sectional observational study. DUPHAT. Dubai, UAE. March 2016.
  • Use of Nutritional Supplements among People Exercising in Gyms in UAE. DUPHAT. Dubai, UAE. March 2016.
  • Use of Slimming Products in UAE: Results of a cross-sectional study. DUPHAT. Dubai, UAE. March 2016.
  • Knowledge, believes and behaviors of Ajman university students toward Osteoporosis. DUPHAT. Dubai, UAE. March 2016.
  • Camel’s milk ameliorates TNBS-induced colitis in rats via down-regulation of inflammatory cytokines and oxidative stress. Experimental Biology. San Diego Convention Center, San Diego, CA, USA. April, 2014
  • Sensitization of Hepatocellular Carcinoma Cells to TRAIL by a Novel Akt/NF-κappaB Signaling Inhibitor. American Association for Cancer Research, Molecular Targeted Therapies: Mechanisms of Resistance, San Diego, California, USA. May 2012.
  • Thymoquinone induces-cell cycle non-specific-cell death in cisplatin-resistant ovarian cancer cell through up-regulation of PTEN expression. American Association for Cancer Research, Molecular Targeted Therapies: Mechanisms of Resistance San Diego, California, USA. May 2012.
  • Thymoquinone induces cell death in glioblasotma cell through production of reactive oxygen species and induction of DNA damage. Proceedings of the American Association for Cancer Research Annual Meeting. Abstract nr 4225. American Association for Cancer Research 102th Annual Meeting, Orlando, FL, USA. April 2011.
  • Combination of cisplatin and tangeretin induces apoptosis in cisplatin-resistant human ovarian cancer cells through modulation of phospho-akt and its downstream substrates. 10th Annual Midwest DNA Repair Symposium. Pittsburgh, PA. May 2008.
  • p38 Map kinase participates in optimal nucleotide excision repair through chromatin remodeling and modulation of DDB2 degradation. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49: 199-200. 2008.
  • Thymoquinone upregulates Pten expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49: 148. 2008.
  • DDB2 is involved in cisplatin sensitivity through enhancement of apoptosis but not DNA repair. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49: 166. 2008.
  • Combination of cisplatin and tangeretin induces apoptosis in cisplatin-resistant human ovarian cancer cells through modulation of phospho-akt and its downstream substrates. Proceedings of the American Association for Cancer Research Annual Meeting. Vol. 49: 803. American Association for Cancer Research 99th Annual Meeting, San Diego, California, 2008.
Memberships, Awards and Honors
  • Faculty Excellence in Research, Ajman University, 2018.
  • Best Research Award, Beni-Suef University, Egypt, 2017.
  • Best Pharmacy Student Thematic Poster from DUPHAT, held in Dubai, UAE, 2017.
  • Beni-Suef university incentive award, Egypt, 2016.
  • Best Professional Poster and Presentation from DUPHAT, held in Dubai, UAE, 2016.
  • Best Pharmacy Student Poster Design from DUPHAT, held in Dubai, UAE, 2016.
  • BioVision. Nxt fellowships award to attend BioVision, 7th edition of the international Life Sciences Forum, held in Lyon, France, 2012.
  • Member of The American Society for Pharmacology and Experimental Therapeutics
  • Member of the American Association for Cancer Research (AACR)
  • Member of MEMBS – Middle East Molecular Biology Sources
  • Member of the Egyptian Association of Pharmacists