Investigating the Role of Tangeretin in the Prevention of Gastric Mucosal Lesions

The findings reported for the first time the gastroprotective actions of Tangeretin in gastric injury which were mediated via suppression of inflammation and oxidative stress, in addition to enhancing the antioxidant and cytoprotective defenses.

Researcher: Elshaimaa Arafa, Associate Professor, College of Pharmacy and Health Sciences

Field of specialization: Pharmacology

Summary

Tangeretin (TG), a polymethoxy citrus flavone, has attracted attention due to its significant antioxidant and antiÔÇÉinflammatory activities. It showed valuable pharmacological actions and protected against cancer, injuries induced by diabetes and liver and renal malfunctions. However, its antiulcer activity has not been investigated.

Our findings reported for the first time the gastroprotective actions of TG in gastric injury which were mediated via suppression of inflammation and oxidative stress in addition to enhancing the antioxidant and the cytoprotective defenses.

Research Impact

This project reported a novel therapy from a naturally occurring flavonoid to overcome gastric ulcer lesions and the underlying mechanism of its effect.

Such new approach for treatment will represent a great addition to gastric ulcer patients especially those who had to stop treatment due to its undesirable side effects.

Research outcomes

The work was presented as a poster in the conference of Experimental Biology 2019 held in Orlando, Florida, USA 6-9 April 2019. Poster title: “Tangeretin Protects against Ethanol-Induced Injury in Gastric Mucosa of Rats via its Antioxidants and anti-Inflammatory Activity”. The abstract was published in the FASEB journal (Link).